Magnetic resonance elastography and diffusion weighted imaging in the evaluation of hepatic fibrosis in chronic hepatitis B

Tiffany P. Hennedige, Gang Wang, Fiona P. Leung, Hind S. Alsaif, Lynette L.S. Teo, Seng Gee Lim, Aileen Wee, Sudhakar K Venkatesh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background/Aims: Comparison of the accuracy of magnetic resonance elastography (MRE) and diffusion weighted imaging (DWI) for the diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB). Methods: In this retrospective analysis, we investigated 63 patients with CHB and liver fibrosis. DWI was performed with both breath-hold (DWIBH) and free-breathing (DWI-FB) sequences (b=0, 500). The mean liver stiffness and apparent diffusion coefficient (ADC) were calculated by drawing regions of interest maps. Fibrosis staging according to the METAVIR system was independently performed by an experienced pathologist. A receiver operating curve (ROC) analysis was conducted to determine the accuracy of MRE, DWI-BH and DWI-FB in the detection and stratification of liver fibrosis. The performance of the detection of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4) was also evaluated by comparing areas under the ROC. Results: There was a moderate and significantly negative correlation between the ADC values and liver stiffness. The accuracies for the detection of ≥F2/≥F3/F4 stage fibrosis with DWI-FB, DWI-BH and MRE were 0.84/0.76/0.72, 0.72/0.83/0.79 and 0.99/0.99/0.98, respectively. The performance of MRE was significantly better than DWI-FB and DWI-BH. There were no significant differences between the performance of DWI-FB and DWI-BH. Conclusions: MRE is more accurate than DWI for the detection and stratification of liver fibrosis in CHB.

Original languageEnglish (US)
Pages (from-to)401-408
Number of pages8
JournalGut and Liver
Volume11
Issue number3
DOIs
StatePublished - May 1 2017

Fingerprint

Elasticity Imaging Techniques
Chronic Hepatitis B
Fibrosis
Liver
Liver Cirrhosis

Keywords

  • Diffusion weighted
  • Elastography
  • Liver cirrhosis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Magnetic resonance elastography and diffusion weighted imaging in the evaluation of hepatic fibrosis in chronic hepatitis B. / Hennedige, Tiffany P.; Wang, Gang; Leung, Fiona P.; Alsaif, Hind S.; Teo, Lynette L.S.; Lim, Seng Gee; Wee, Aileen; Venkatesh, Sudhakar K.

In: Gut and Liver, Vol. 11, No. 3, 01.05.2017, p. 401-408.

Research output: Contribution to journalArticle

Hennedige, Tiffany P. ; Wang, Gang ; Leung, Fiona P. ; Alsaif, Hind S. ; Teo, Lynette L.S. ; Lim, Seng Gee ; Wee, Aileen ; Venkatesh, Sudhakar K. / Magnetic resonance elastography and diffusion weighted imaging in the evaluation of hepatic fibrosis in chronic hepatitis B. In: Gut and Liver. 2017 ; Vol. 11, No. 3. pp. 401-408.
@article{8bd521468b524afe945982aa7f88aa46,
title = "Magnetic resonance elastography and diffusion weighted imaging in the evaluation of hepatic fibrosis in chronic hepatitis B",
abstract = "Background/Aims: Comparison of the accuracy of magnetic resonance elastography (MRE) and diffusion weighted imaging (DWI) for the diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB). Methods: In this retrospective analysis, we investigated 63 patients with CHB and liver fibrosis. DWI was performed with both breath-hold (DWIBH) and free-breathing (DWI-FB) sequences (b=0, 500). The mean liver stiffness and apparent diffusion coefficient (ADC) were calculated by drawing regions of interest maps. Fibrosis staging according to the METAVIR system was independently performed by an experienced pathologist. A receiver operating curve (ROC) analysis was conducted to determine the accuracy of MRE, DWI-BH and DWI-FB in the detection and stratification of liver fibrosis. The performance of the detection of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4) was also evaluated by comparing areas under the ROC. Results: There was a moderate and significantly negative correlation between the ADC values and liver stiffness. The accuracies for the detection of ≥F2/≥F3/F4 stage fibrosis with DWI-FB, DWI-BH and MRE were 0.84/0.76/0.72, 0.72/0.83/0.79 and 0.99/0.99/0.98, respectively. The performance of MRE was significantly better than DWI-FB and DWI-BH. There were no significant differences between the performance of DWI-FB and DWI-BH. Conclusions: MRE is more accurate than DWI for the detection and stratification of liver fibrosis in CHB.",
keywords = "Diffusion weighted, Elastography, Liver cirrhosis",
author = "Hennedige, {Tiffany P.} and Gang Wang and Leung, {Fiona P.} and Alsaif, {Hind S.} and Teo, {Lynette L.S.} and Lim, {Seng Gee} and Aileen Wee and Venkatesh, {Sudhakar K}",
year = "2017",
month = "5",
day = "1",
doi = "10.5009/gnl16079",
language = "English (US)",
volume = "11",
pages = "401--408",
journal = "Gut and Liver",
issn = "1976-2283",
publisher = "Joe Bok Chung",
number = "3",

}

TY - JOUR

T1 - Magnetic resonance elastography and diffusion weighted imaging in the evaluation of hepatic fibrosis in chronic hepatitis B

AU - Hennedige, Tiffany P.

AU - Wang, Gang

AU - Leung, Fiona P.

AU - Alsaif, Hind S.

AU - Teo, Lynette L.S.

AU - Lim, Seng Gee

AU - Wee, Aileen

AU - Venkatesh, Sudhakar K

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background/Aims: Comparison of the accuracy of magnetic resonance elastography (MRE) and diffusion weighted imaging (DWI) for the diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB). Methods: In this retrospective analysis, we investigated 63 patients with CHB and liver fibrosis. DWI was performed with both breath-hold (DWIBH) and free-breathing (DWI-FB) sequences (b=0, 500). The mean liver stiffness and apparent diffusion coefficient (ADC) were calculated by drawing regions of interest maps. Fibrosis staging according to the METAVIR system was independently performed by an experienced pathologist. A receiver operating curve (ROC) analysis was conducted to determine the accuracy of MRE, DWI-BH and DWI-FB in the detection and stratification of liver fibrosis. The performance of the detection of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4) was also evaluated by comparing areas under the ROC. Results: There was a moderate and significantly negative correlation between the ADC values and liver stiffness. The accuracies for the detection of ≥F2/≥F3/F4 stage fibrosis with DWI-FB, DWI-BH and MRE were 0.84/0.76/0.72, 0.72/0.83/0.79 and 0.99/0.99/0.98, respectively. The performance of MRE was significantly better than DWI-FB and DWI-BH. There were no significant differences between the performance of DWI-FB and DWI-BH. Conclusions: MRE is more accurate than DWI for the detection and stratification of liver fibrosis in CHB.

AB - Background/Aims: Comparison of the accuracy of magnetic resonance elastography (MRE) and diffusion weighted imaging (DWI) for the diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB). Methods: In this retrospective analysis, we investigated 63 patients with CHB and liver fibrosis. DWI was performed with both breath-hold (DWIBH) and free-breathing (DWI-FB) sequences (b=0, 500). The mean liver stiffness and apparent diffusion coefficient (ADC) were calculated by drawing regions of interest maps. Fibrosis staging according to the METAVIR system was independently performed by an experienced pathologist. A receiver operating curve (ROC) analysis was conducted to determine the accuracy of MRE, DWI-BH and DWI-FB in the detection and stratification of liver fibrosis. The performance of the detection of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4) was also evaluated by comparing areas under the ROC. Results: There was a moderate and significantly negative correlation between the ADC values and liver stiffness. The accuracies for the detection of ≥F2/≥F3/F4 stage fibrosis with DWI-FB, DWI-BH and MRE were 0.84/0.76/0.72, 0.72/0.83/0.79 and 0.99/0.99/0.98, respectively. The performance of MRE was significantly better than DWI-FB and DWI-BH. There were no significant differences between the performance of DWI-FB and DWI-BH. Conclusions: MRE is more accurate than DWI for the detection and stratification of liver fibrosis in CHB.

KW - Diffusion weighted

KW - Elastography

KW - Liver cirrhosis

UR - http://www.scopus.com/inward/record.url?scp=85018789563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018789563&partnerID=8YFLogxK

U2 - 10.5009/gnl16079

DO - 10.5009/gnl16079

M3 - Article

VL - 11

SP - 401

EP - 408

JO - Gut and Liver

JF - Gut and Liver

SN - 1976-2283

IS - 3

ER -