Magnetic Resonance Elastography: A Novel Technique for the Detection of Hepatic Fibrosis and Hepatocellular Carcinoma After the Fontan Operation

Joseph T. Poterucha, Jonathan N. Johnson, Muhammad Yasir Qureshi, Patrick W. O'Leary, Patrick Sequeira Kamath, Ryan J. Lennon, Crystal R. Bonnichsen, Phillip M. Young, Sudhakar K Venkatesh, Richard Lorne Ehman, Sounak Gupta, Thomas Christopher Smyrk, Joseph A. Dearani, Carole A. Warnes, Frank Cetta

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the utility of magnetic resonance elastography (MRE) in screening patients for hepatic fibrosis, cirrhosis, and hepatocellular carcinoma after the Fontan operation. Patients and Methods: Hepatic MRE was performed in conjunction with cardiac magnetic resonance imaging in patients who had undergone a Fontan operation between 2010 and 2014. Liver stiffness was calculated using previously reported techniques. Comparisons to available clinical, laboratory, imaging, and histopathologic data were made. Results: Overall, 50 patients at a median age of 25 years (range, 21-33 years) who had undergone a Fontan operation were evaluated. The median interval between Fontan operation and MRE was 22 years (range, 16-26 years). The mean liver stiffness values were increased: 5.5±1.4 kPa relative to normal participants. Liver stiffness directly correlated with liver biopsy-derived total fibrosis score, time since operation, mean Fontan pressure, γ-glutamyltransferase level, Model for End-Stage Liver Disease score, creatinine level, and pulmonary vascular resistance index. Liver stiffness was inversely correlated with cardiac index. All 3 participants with hepatic nodules exhibiting decreased contrast uptake on delayed postcontrast imaging and increased nodule stiffness had biopsy-proven hepatocellular carcinoma. Conclusion: The association between hepatic stiffness and fibrosis scores, Model for End-Stage Liver Disease scores, and γ-glutamyltransferase level suggests that MRE may be useful in detecting (and possibly quantifying) hepatic cirrhosis in patients after the Fontan operation. The correlation between stiffness and post-Fontan time interval, mean Fontan pressure, pulmonary vascular resistance index, and reduced cardiac index suggests a role for long-term hepatic congestion in creating these hepatic abnormalities. Magnetic resonance elastography was useful in detecting abnormal nodules ultimately diagnosed as hepatocellular carcinoma. The relationship between stiffness with advanced fibrosis and hepatocellular carcinoma provides a strong argument for additional study and broader application of MRE in these patients.

Original languageEnglish (US)
Pages (from-to)882-894
Number of pages13
JournalMayo Clinic Proceedings
Volume90
Issue number7
DOIs
StatePublished - Jul 1 2015

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Fontan Procedure
Elasticity Imaging Techniques
Hepatocellular Carcinoma
Fibrosis
Liver
End Stage Liver Disease
Liver Cirrhosis
Vascular Resistance
Biopsy
Pressure
Creatinine
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Medicine(all)

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Magnetic Resonance Elastography : A Novel Technique for the Detection of Hepatic Fibrosis and Hepatocellular Carcinoma After the Fontan Operation. / Poterucha, Joseph T.; Johnson, Jonathan N.; Qureshi, Muhammad Yasir; O'Leary, Patrick W.; Kamath, Patrick Sequeira; Lennon, Ryan J.; Bonnichsen, Crystal R.; Young, Phillip M.; Venkatesh, Sudhakar K; Ehman, Richard Lorne; Gupta, Sounak; Smyrk, Thomas Christopher; Dearani, Joseph A.; Warnes, Carole A.; Cetta, Frank.

In: Mayo Clinic Proceedings, Vol. 90, No. 7, 01.07.2015, p. 882-894.

Research output: Contribution to journalArticle

Poterucha, JT, Johnson, JN, Qureshi, MY, O'Leary, PW, Kamath, PS, Lennon, RJ, Bonnichsen, CR, Young, PM, Venkatesh, SK, Ehman, RL, Gupta, S, Smyrk, TC, Dearani, JA, Warnes, CA & Cetta, F 2015, 'Magnetic Resonance Elastography: A Novel Technique for the Detection of Hepatic Fibrosis and Hepatocellular Carcinoma After the Fontan Operation', Mayo Clinic Proceedings, vol. 90, no. 7, pp. 882-894. https://doi.org/10.1016/j.mayocp.2015.04.020
Poterucha, Joseph T. ; Johnson, Jonathan N. ; Qureshi, Muhammad Yasir ; O'Leary, Patrick W. ; Kamath, Patrick Sequeira ; Lennon, Ryan J. ; Bonnichsen, Crystal R. ; Young, Phillip M. ; Venkatesh, Sudhakar K ; Ehman, Richard Lorne ; Gupta, Sounak ; Smyrk, Thomas Christopher ; Dearani, Joseph A. ; Warnes, Carole A. ; Cetta, Frank. / Magnetic Resonance Elastography : A Novel Technique for the Detection of Hepatic Fibrosis and Hepatocellular Carcinoma After the Fontan Operation. In: Mayo Clinic Proceedings. 2015 ; Vol. 90, No. 7. pp. 882-894.
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abstract = "Objective: To evaluate the utility of magnetic resonance elastography (MRE) in screening patients for hepatic fibrosis, cirrhosis, and hepatocellular carcinoma after the Fontan operation. Patients and Methods: Hepatic MRE was performed in conjunction with cardiac magnetic resonance imaging in patients who had undergone a Fontan operation between 2010 and 2014. Liver stiffness was calculated using previously reported techniques. Comparisons to available clinical, laboratory, imaging, and histopathologic data were made. Results: Overall, 50 patients at a median age of 25 years (range, 21-33 years) who had undergone a Fontan operation were evaluated. The median interval between Fontan operation and MRE was 22 years (range, 16-26 years). The mean liver stiffness values were increased: 5.5±1.4 kPa relative to normal participants. Liver stiffness directly correlated with liver biopsy-derived total fibrosis score, time since operation, mean Fontan pressure, γ-glutamyltransferase level, Model for End-Stage Liver Disease score, creatinine level, and pulmonary vascular resistance index. Liver stiffness was inversely correlated with cardiac index. All 3 participants with hepatic nodules exhibiting decreased contrast uptake on delayed postcontrast imaging and increased nodule stiffness had biopsy-proven hepatocellular carcinoma. Conclusion: The association between hepatic stiffness and fibrosis scores, Model for End-Stage Liver Disease scores, and γ-glutamyltransferase level suggests that MRE may be useful in detecting (and possibly quantifying) hepatic cirrhosis in patients after the Fontan operation. The correlation between stiffness and post-Fontan time interval, mean Fontan pressure, pulmonary vascular resistance index, and reduced cardiac index suggests a role for long-term hepatic congestion in creating these hepatic abnormalities. Magnetic resonance elastography was useful in detecting abnormal nodules ultimately diagnosed as hepatocellular carcinoma. The relationship between stiffness with advanced fibrosis and hepatocellular carcinoma provides a strong argument for additional study and broader application of MRE in these patients.",
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AU - Qureshi, Muhammad Yasir

AU - O'Leary, Patrick W.

AU - Kamath, Patrick Sequeira

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N2 - Objective: To evaluate the utility of magnetic resonance elastography (MRE) in screening patients for hepatic fibrosis, cirrhosis, and hepatocellular carcinoma after the Fontan operation. Patients and Methods: Hepatic MRE was performed in conjunction with cardiac magnetic resonance imaging in patients who had undergone a Fontan operation between 2010 and 2014. Liver stiffness was calculated using previously reported techniques. Comparisons to available clinical, laboratory, imaging, and histopathologic data were made. Results: Overall, 50 patients at a median age of 25 years (range, 21-33 years) who had undergone a Fontan operation were evaluated. The median interval between Fontan operation and MRE was 22 years (range, 16-26 years). The mean liver stiffness values were increased: 5.5±1.4 kPa relative to normal participants. Liver stiffness directly correlated with liver biopsy-derived total fibrosis score, time since operation, mean Fontan pressure, γ-glutamyltransferase level, Model for End-Stage Liver Disease score, creatinine level, and pulmonary vascular resistance index. Liver stiffness was inversely correlated with cardiac index. All 3 participants with hepatic nodules exhibiting decreased contrast uptake on delayed postcontrast imaging and increased nodule stiffness had biopsy-proven hepatocellular carcinoma. Conclusion: The association between hepatic stiffness and fibrosis scores, Model for End-Stage Liver Disease scores, and γ-glutamyltransferase level suggests that MRE may be useful in detecting (and possibly quantifying) hepatic cirrhosis in patients after the Fontan operation. The correlation between stiffness and post-Fontan time interval, mean Fontan pressure, pulmonary vascular resistance index, and reduced cardiac index suggests a role for long-term hepatic congestion in creating these hepatic abnormalities. Magnetic resonance elastography was useful in detecting abnormal nodules ultimately diagnosed as hepatocellular carcinoma. The relationship between stiffness with advanced fibrosis and hepatocellular carcinoma provides a strong argument for additional study and broader application of MRE in these patients.

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