Macular pigment optical density measured by Dual-Wavelength autofluorescence imaging in diabetic and Nondiabetic patients: A comparative Study

Verônica Castro Lima, Richard B. Rosen, Mauricio Maia, Tiago Santos Prata, Syril Dorairaj, Michel Eid Farah, Juliana Sallum

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

PURPOSE. To compare macular pigment optical density (MPOD) in type 2 diabetic and nondiabetic patients by using dualwavelength autofluorescence imaging and to investigate the correlation of MPOD with glycosylated hemoglobin (HbA1C) and serum lipid levels. METHODS. Forty-three patients were divided into groups 1 (controls, n = 14), 2 (diabetic without retinopathy, n = 17), and 3 (diabetic with mild nonproliferative retinopathy, n = 12). MPOD was measured with a modified confocal scanning laser ophthalmoscope and compared among groups (analysis of variance). The correlation of HbA1C and serum lipid (HDL, LDL, total cholesterol, and triglycerides) levels with MPOD was determined for each group (linear regression analysis). RESULTS. Mean ± SD ages in groups 1 (56.2 ± 11.7 years), 2 (58.6 ± 11.5 years), and 3 (62.8 ± 9.8 years) were similar (P = 0.324). Mean MPOD averaged in a 2°-diameter circle around the fovea was significantly different between the three groups: 1, (0.29 ± 0.07 density units [DU]), 2 (0.22 ± 0.09 DU), and 3 (0.14 ± 0.05 DU) (P < 0.001). There was a significant difference in mean MPOD levels at 0.5° between groups 1 (0.51 ± 0.12 DU) and 2 (0.24 ± 0.11 DU; P < 0.001), but not between groups 2 and 3 (0.33 ± 0.15 DU; P < 0.05). A significant inverse correlation was observed between HbA1C levels and mean MPOD, averaged at 2° around the fovea in all patients (r=-0.63, P < 0.001). No significant correlations were found between MPOD and serum lipid levels or age. CONCLUSIONS. Type 2 diabetic patients, with or without retinopathy, had reduced MPOD when compared with that in nondiabetic patients. In addition, a significant inverse correlation between MPOD and HbA1C levels was observed.

Original languageEnglish (US)
Pages (from-to)5840-5845
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume51
Issue number11
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

Fingerprint

Optical Imaging
Lipids
Serum
Macular Pigment
Ophthalmoscopes
Glycosylated Hemoglobin A
Diabetic Retinopathy
LDL Cholesterol
Linear Models
Analysis of Variance
Lasers
Age Groups
Regression Analysis
Control Groups

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Macular pigment optical density measured by Dual-Wavelength autofluorescence imaging in diabetic and Nondiabetic patients : A comparative Study. / Lima, Verônica Castro; Rosen, Richard B.; Maia, Mauricio; Prata, Tiago Santos; Dorairaj, Syril; Farah, Michel Eid; Sallum, Juliana.

In: Investigative Ophthalmology and Visual Science, Vol. 51, No. 11, 01.11.2010, p. 5840-5845.

Research output: Contribution to journalArticle

Lima, Verônica Castro ; Rosen, Richard B. ; Maia, Mauricio ; Prata, Tiago Santos ; Dorairaj, Syril ; Farah, Michel Eid ; Sallum, Juliana. / Macular pigment optical density measured by Dual-Wavelength autofluorescence imaging in diabetic and Nondiabetic patients : A comparative Study. In: Investigative Ophthalmology and Visual Science. 2010 ; Vol. 51, No. 11. pp. 5840-5845.
@article{6943ea2ea5b448789121791fc7403b72,
title = "Macular pigment optical density measured by Dual-Wavelength autofluorescence imaging in diabetic and Nondiabetic patients: A comparative Study",
abstract = "PURPOSE. To compare macular pigment optical density (MPOD) in type 2 diabetic and nondiabetic patients by using dualwavelength autofluorescence imaging and to investigate the correlation of MPOD with glycosylated hemoglobin (HbA1C) and serum lipid levels. METHODS. Forty-three patients were divided into groups 1 (controls, n = 14), 2 (diabetic without retinopathy, n = 17), and 3 (diabetic with mild nonproliferative retinopathy, n = 12). MPOD was measured with a modified confocal scanning laser ophthalmoscope and compared among groups (analysis of variance). The correlation of HbA1C and serum lipid (HDL, LDL, total cholesterol, and triglycerides) levels with MPOD was determined for each group (linear regression analysis). RESULTS. Mean ± SD ages in groups 1 (56.2 ± 11.7 years), 2 (58.6 ± 11.5 years), and 3 (62.8 ± 9.8 years) were similar (P = 0.324). Mean MPOD averaged in a 2°-diameter circle around the fovea was significantly different between the three groups: 1, (0.29 ± 0.07 density units [DU]), 2 (0.22 ± 0.09 DU), and 3 (0.14 ± 0.05 DU) (P < 0.001). There was a significant difference in mean MPOD levels at 0.5° between groups 1 (0.51 ± 0.12 DU) and 2 (0.24 ± 0.11 DU; P < 0.001), but not between groups 2 and 3 (0.33 ± 0.15 DU; P < 0.05). A significant inverse correlation was observed between HbA1C levels and mean MPOD, averaged at 2° around the fovea in all patients (r=-0.63, P < 0.001). No significant correlations were found between MPOD and serum lipid levels or age. CONCLUSIONS. Type 2 diabetic patients, with or without retinopathy, had reduced MPOD when compared with that in nondiabetic patients. In addition, a significant inverse correlation between MPOD and HbA1C levels was observed.",
author = "Lima, {Ver{\^o}nica Castro} and Rosen, {Richard B.} and Mauricio Maia and Prata, {Tiago Santos} and Syril Dorairaj and Farah, {Michel Eid} and Juliana Sallum",
year = "2010",
month = "11",
day = "1",
doi = "10.1167/iovs.09-4695",
language = "English (US)",
volume = "51",
pages = "5840--5845",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "11",

}

TY - JOUR

T1 - Macular pigment optical density measured by Dual-Wavelength autofluorescence imaging in diabetic and Nondiabetic patients

T2 - A comparative Study

AU - Lima, Verônica Castro

AU - Rosen, Richard B.

AU - Maia, Mauricio

AU - Prata, Tiago Santos

AU - Dorairaj, Syril

AU - Farah, Michel Eid

AU - Sallum, Juliana

PY - 2010/11/1

Y1 - 2010/11/1

N2 - PURPOSE. To compare macular pigment optical density (MPOD) in type 2 diabetic and nondiabetic patients by using dualwavelength autofluorescence imaging and to investigate the correlation of MPOD with glycosylated hemoglobin (HbA1C) and serum lipid levels. METHODS. Forty-three patients were divided into groups 1 (controls, n = 14), 2 (diabetic without retinopathy, n = 17), and 3 (diabetic with mild nonproliferative retinopathy, n = 12). MPOD was measured with a modified confocal scanning laser ophthalmoscope and compared among groups (analysis of variance). The correlation of HbA1C and serum lipid (HDL, LDL, total cholesterol, and triglycerides) levels with MPOD was determined for each group (linear regression analysis). RESULTS. Mean ± SD ages in groups 1 (56.2 ± 11.7 years), 2 (58.6 ± 11.5 years), and 3 (62.8 ± 9.8 years) were similar (P = 0.324). Mean MPOD averaged in a 2°-diameter circle around the fovea was significantly different between the three groups: 1, (0.29 ± 0.07 density units [DU]), 2 (0.22 ± 0.09 DU), and 3 (0.14 ± 0.05 DU) (P < 0.001). There was a significant difference in mean MPOD levels at 0.5° between groups 1 (0.51 ± 0.12 DU) and 2 (0.24 ± 0.11 DU; P < 0.001), but not between groups 2 and 3 (0.33 ± 0.15 DU; P < 0.05). A significant inverse correlation was observed between HbA1C levels and mean MPOD, averaged at 2° around the fovea in all patients (r=-0.63, P < 0.001). No significant correlations were found between MPOD and serum lipid levels or age. CONCLUSIONS. Type 2 diabetic patients, with or without retinopathy, had reduced MPOD when compared with that in nondiabetic patients. In addition, a significant inverse correlation between MPOD and HbA1C levels was observed.

AB - PURPOSE. To compare macular pigment optical density (MPOD) in type 2 diabetic and nondiabetic patients by using dualwavelength autofluorescence imaging and to investigate the correlation of MPOD with glycosylated hemoglobin (HbA1C) and serum lipid levels. METHODS. Forty-three patients were divided into groups 1 (controls, n = 14), 2 (diabetic without retinopathy, n = 17), and 3 (diabetic with mild nonproliferative retinopathy, n = 12). MPOD was measured with a modified confocal scanning laser ophthalmoscope and compared among groups (analysis of variance). The correlation of HbA1C and serum lipid (HDL, LDL, total cholesterol, and triglycerides) levels with MPOD was determined for each group (linear regression analysis). RESULTS. Mean ± SD ages in groups 1 (56.2 ± 11.7 years), 2 (58.6 ± 11.5 years), and 3 (62.8 ± 9.8 years) were similar (P = 0.324). Mean MPOD averaged in a 2°-diameter circle around the fovea was significantly different between the three groups: 1, (0.29 ± 0.07 density units [DU]), 2 (0.22 ± 0.09 DU), and 3 (0.14 ± 0.05 DU) (P < 0.001). There was a significant difference in mean MPOD levels at 0.5° between groups 1 (0.51 ± 0.12 DU) and 2 (0.24 ± 0.11 DU; P < 0.001), but not between groups 2 and 3 (0.33 ± 0.15 DU; P < 0.05). A significant inverse correlation was observed between HbA1C levels and mean MPOD, averaged at 2° around the fovea in all patients (r=-0.63, P < 0.001). No significant correlations were found between MPOD and serum lipid levels or age. CONCLUSIONS. Type 2 diabetic patients, with or without retinopathy, had reduced MPOD when compared with that in nondiabetic patients. In addition, a significant inverse correlation between MPOD and HbA1C levels was observed.

UR - http://www.scopus.com/inward/record.url?scp=79956047782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79956047782&partnerID=8YFLogxK

U2 - 10.1167/iovs.09-4695

DO - 10.1167/iovs.09-4695

M3 - Article

C2 - 20505210

AN - SCOPUS:79956047782

VL - 51

SP - 5840

EP - 5845

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 11

ER -