Abstract
Purpose: To evaluate a tissue sealant (autologous cryoprecipitate activated with bovine thrombin) as an adjuvant in macular hole surgery. Methods: Sixty-nine patients with stage 2, 3, or 4 full-thickness macular hole were enrolled consecutively in a prospective pilot study. Anatomic closure of the macular holes with a single operation was the primary outcome. Fifty-eight patients had pre- and postoperative standardized measurements including best refracted visual acuity, reading speed, and contrast sensitivity. Group A patients (45) had primary macular holes; Group B patients (13) had recurrent macular holes or macular holes with 'other' retinal pathology. Surgical technique was standardized and membrane dissections were optional. Results: The anatomic closure rate was 80% with a minimum of 6 months follow-up. Mean improvement in visual acuity for Group A (2.9 ± 0.4 lines) was significantly better than for Group B (0.8 ± 0.5 lines; P = 0.008). Eyes that underwent internal limiting membrane (ILM) dissections had an anatomic closure rate of 96% (23/24), compared with 71% (32/45) in 'non-ILM' cases (P = 0.034). Adverse reactions included sterile hypopyon (10%), intraretinal hemorrhage (9%), pigmentary hyperplasia (3%), and retinal detachment (3%). Conclusion: Tissue sealants should be evaluated as an adjuvant in macular hole surgery in a randomized clinical trial. Inflammatory reactions may occur in some patients. Internal limiting membrane dissection may improve anatomic closure rates without adversely affecting the visual acuity.
Original language | English (US) |
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Pages (from-to) | 322-329 |
Number of pages | 8 |
Journal | Retina |
Volume | 18 |
Issue number | 4 |
DOIs | |
State | Published - 1998 |
Keywords
- Autologous cryoprecipitate
- Bovine thrombin
- Fibrin sealants
- Macular hole
- Pars plana vitrectomy
ASJC Scopus subject areas
- Ophthalmology