Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor

Andrew D. Badley, David Dockrell, Margaret Simpson, Ron Schut, David H. Lynch, Paul Leibson, Carlos V. Paya

Research output: Contribution to journalArticlepeer-review

214 Scopus citations


Apoptosis of bystander uninfected CD4+ T lymphocytes by neighboring HIV-infected cells is observed in cell culture and in lymphoid tissue of HIV-infected individuals. This study addresses whether antigen-presenting cells such as human macrophages mediate apoptosis of CD4+ T cells from HIV- infected individuals. Uninfected human macrophages, and to a larger degree, HIV-infected macrophages mediate apoptosis of T cells from HIV-infected, but not from uninfected control individuals. This macrophage-dependent killing targets CD4+, but not CD8+ T lymphocytes from HIV-infected individuals, and direct contact between macrophages and lymphocytes is required. Additional analyses indicated that the apoptosis-inducing ligands, FasL and tumor necrosis factor (TNF), mediate this macrophage-induced apoptosis of CD4+ T cells. These results support a role for macrophage-associated FasL and TNF in the selective depletion of CD4+ T cells in HIV-infected individuals.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalJournal of Experimental Medicine
Issue number1
StatePublished - Jan 6 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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