Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor

Andrew David Badley, David Dockrell, Margaret Simpson, Ron Schut, David H. Lynch, Paul Leibson, Carlos V. Paya

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

Apoptosis of bystander uninfected CD4+ T lymphocytes by neighboring HIV-infected cells is observed in cell culture and in lymphoid tissue of HIV-infected individuals. This study addresses whether antigen-presenting cells such as human macrophages mediate apoptosis of CD4+ T cells from HIV- infected individuals. Uninfected human macrophages, and to a larger degree, HIV-infected macrophages mediate apoptosis of T cells from HIV-infected, but not from uninfected control individuals. This macrophage-dependent killing targets CD4+, but not CD8+ T lymphocytes from HIV-infected individuals, and direct contact between macrophages and lymphocytes is required. Additional analyses indicated that the apoptosis-inducing ligands, FasL and tumor necrosis factor (TNF), mediate this macrophage-induced apoptosis of CD4+ T cells. These results support a role for macrophage-associated FasL and TNF in the selective depletion of CD4+ T cells in HIV-infected individuals.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalJournal of Experimental Medicine
Volume185
Issue number1
DOIs
StatePublished - Jan 6 1997

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Tumor Necrosis Factor-alpha
Macrophages
HIV
Apoptosis
T-Lymphocytes
Lymphoid Tissue
Antigen-Presenting Cells
Cell Culture Techniques
Lymphocytes
Ligands

ASJC Scopus subject areas

  • Immunology

Cite this

Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor. / Badley, Andrew David; Dockrell, David; Simpson, Margaret; Schut, Ron; Lynch, David H.; Leibson, Paul; Paya, Carlos V.

In: Journal of Experimental Medicine, Vol. 185, No. 1, 06.01.1997, p. 55-64.

Research output: Contribution to journalArticle

Badley, Andrew David ; Dockrell, David ; Simpson, Margaret ; Schut, Ron ; Lynch, David H. ; Leibson, Paul ; Paya, Carlos V. / Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor. In: Journal of Experimental Medicine. 1997 ; Vol. 185, No. 1. pp. 55-64.
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