M1 muscarinic acetylcholine receptor in Alzheimer's disease

Shangtong Jiang; Yanfang Li; Cuilin Zhang; Yingjun Zhao; Guojun Bu; Huaxi Xu; Yun Wu Zhang

doi:10.1007/s12264-013-1406-z

M1 muscarinic acetylcholine receptor in Alzheimer's disease

Shangtong Jiang, Yanfang Li, Cuilin Zhang, Yingjun Zhao, Guojun Bu, Huaxi Xu, Yun Wu Zhang

Neuroscience

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment.

Original language	English (US)
Pages (from-to)	295-307
Number of pages	13
Journal	Neuroscience Bulletin
Volume	30
Issue number	2
DOIs	https://doi.org/10.1007/s12264-013-1406-z
State	Published - Apr 2014

Keywords

Alzheimer's disease
M1 muscarinic acetylcholine receptor
agonist
amyloid
cholinergic hypofunction
tau

ASJC Scopus subject areas

General Neuroscience
Physiology

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10.1007/s12264-013-1406-z

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title = "M1 muscarinic acetylcholine receptor in Alzheimer's disease",

abstract = "The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment.",

keywords = "Alzheimer's disease, M1 muscarinic acetylcholine receptor, agonist, amyloid, cholinergic hypofunction, tau",

author = "Shangtong Jiang and Yanfang Li and Cuilin Zhang and Yingjun Zhao and Guojun Bu and Huaxi Xu and Zhang, {Yun Wu}",

note = "Funding Information: This review was supported by grants from the National Institutes of Health, USA (R01AG038710, R01AG021173, R01AG044420 and R01NS046673), the Alzheimer{\textquoteright}s Association, the National Natural Science Foundation of China (91332112, 81225008 and 81161120496), Fundamental Research Funds for the Central Universities of China, and the Fok Ying Tung Education Foundation.",

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doi = "10.1007/s12264-013-1406-z",

language = "English (US)",

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AU - Jiang, Shangtong

AU - Li, Yanfang

AU - Zhang, Cuilin

AU - Zhao, Yingjun

AU - Bu, Guojun

AU - Xu, Huaxi

AU - Zhang, Yun Wu

N1 - Funding Information: This review was supported by grants from the National Institutes of Health, USA (R01AG038710, R01AG021173, R01AG044420 and R01NS046673), the Alzheimer’s Association, the National Natural Science Foundation of China (91332112, 81225008 and 81161120496), Fundamental Research Funds for the Central Universities of China, and the Fok Ying Tung Education Foundation.

PY - 2014/4

Y1 - 2014/4

N2 - The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment.

AB - The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment.

KW - Alzheimer's disease

KW - M1 muscarinic acetylcholine receptor

KW - agonist

KW - amyloid

KW - cholinergic hypofunction

KW - tau

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M1 muscarinic acetylcholine receptor in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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