M1 muscarinic acetylcholine receptor in Alzheimer's disease

Shangtong Jiang, Yanfang Li, Cuilin Zhang, Yingjun Zhao, Guojun Bu, Huaxi Xu, Yun Wu Zhang

Research output: Contribution to journalReview article

72 Scopus citations

Abstract

The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment.

Original languageEnglish (US)
Pages (from-to)295-307
Number of pages13
JournalNeuroscience Bulletin
Volume30
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • Alzheimer's disease
  • M1 muscarinic acetylcholine receptor
  • agonist
  • amyloid
  • cholinergic hypofunction
  • tau

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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  • Cite this

    Jiang, S., Li, Y., Zhang, C., Zhao, Y., Bu, G., Xu, H., & Zhang, Y. W. (2014). M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neuroscience Bulletin, 30(2), 295-307. https://doi.org/10.1007/s12264-013-1406-z