Lynch syndrome-associated colorectal cancer

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A 48-year-old man presents with intermittent lower abdominal pain on his right side and reports a weight loss of 4.5 kg (10 lb). He is married and has two healthy teenage children. The physical examination is remarkable for the presence of blood in the stool on digital rectal examination. The hemoglobin level is 11.4 g per deciliter. His mother had a gynecologic cancer at 45 years of age, and his maternal grandfather had colorectal cancer at 63 years of age. Computed tomography of the abdomen and pelvis shows thickening of the cecal wall and pericecal adenopathy. A colonoscopy reveals a polypoid cecal mass, and a biopsy shows poorly differentiated adenocarcinoma. How should this patient be further evaluated and treated?

Original languageEnglish (US)
Pages (from-to)764-773
Number of pages10
JournalNew England Journal of Medicine
Volume379
Issue number8
DOIs
StatePublished - Aug 23 2018

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Hereditary Nonpolyposis Colorectal Neoplasms
Digital Rectal Examination
Maternal Age
Colonoscopy
Pelvis
Abdomen
Abdominal Pain
Physical Examination
Weight Loss
Colorectal Neoplasms
Hemoglobins
Adenocarcinoma
Tomography
Mothers
Biopsy
Neoplasms
Grandparents
Lymphadenopathy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lynch syndrome-associated colorectal cancer. / Sinicrope, Frank A.

In: New England Journal of Medicine, Vol. 379, No. 8, 23.08.2018, p. 764-773.

Research output: Contribution to journalArticle

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