Lymphoma in soft tissue: A clinicopathologic study of 19 cases

Diva R. Salomao, Antonio G. Nascimento, Ricardo V. Lloyd, Michael G. Chen, Thomas Matthew Habermann, John G. Strickler

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The authors retrospectively reviewed 19 patients who presented with lymphoma as soft tissue masses, without evidence of lymph node or skin involvement. Sites of involvement included lower extremity (seven), upper extremity (six), chest wall (three), gluteal region (two), and frontal subgaleal region (one). Histological and immunophenotypic studies revealed 12 large cell lymphomas (11 B cell and one T cell), two small noncleaved cell lymphomas (B-cell phenotype), and five low grade B-cell lymphomas (two small lymphocytic and three follicular mixed lymphomas). Patients with large cell lymphoma, including seven patients with stages I and II and five patients with stage IV, were treated with anthracycline-based chemotherapy, with or without radiation therapy. One half of these patients are dead of disease, including four of seven with low stage disease. The two patients with small noncleaved cell lymphoma had stage IE disease and were treated with chemotherapy; one died at 11 months, and the other is alive and disease free at 65 months. Patients with low grade B-cell lymphoma included four stage IE patients who were treated with radiation and one stage IV patient treated with chemotherapy. Two patients are alive and disease free, and three are dead of unrelated causes. The authors conclude that malignant lymphomas initially diagnosed in soft tissues are most commonly large cell lymphomas with a B-cell phenotype.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalHuman Pathology
Volume27
Issue number3
DOIs
StatePublished - 1996

Fingerprint

Lymphoma
Non-Hodgkin's Lymphoma
B-Cell Lymphoma
Drug Therapy
B-Lymphocytes
Phenotype
Follicular Lymphoma
Buttocks
Anthracyclines
Thoracic Wall
Upper Extremity
Lower Extremity
Radiotherapy
Lymph Nodes
Radiation
T-Lymphocytes
Skin

Keywords

  • Epstein-Barr virus
  • immunohistochemistry
  • lymphoma
  • soft tissue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Salomao, D. R., Nascimento, A. G., Lloyd, R. V., Chen, M. G., Habermann, T. M., & Strickler, J. G. (1996). Lymphoma in soft tissue: A clinicopathologic study of 19 cases. Human Pathology, 27(3), 253-257. https://doi.org/10.1016/S0046-8177(96)90065-9

Lymphoma in soft tissue : A clinicopathologic study of 19 cases. / Salomao, Diva R.; Nascimento, Antonio G.; Lloyd, Ricardo V.; Chen, Michael G.; Habermann, Thomas Matthew; Strickler, John G.

In: Human Pathology, Vol. 27, No. 3, 1996, p. 253-257.

Research output: Contribution to journalArticle

Salomao, DR, Nascimento, AG, Lloyd, RV, Chen, MG, Habermann, TM & Strickler, JG 1996, 'Lymphoma in soft tissue: A clinicopathologic study of 19 cases', Human Pathology, vol. 27, no. 3, pp. 253-257. https://doi.org/10.1016/S0046-8177(96)90065-9
Salomao, Diva R. ; Nascimento, Antonio G. ; Lloyd, Ricardo V. ; Chen, Michael G. ; Habermann, Thomas Matthew ; Strickler, John G. / Lymphoma in soft tissue : A clinicopathologic study of 19 cases. In: Human Pathology. 1996 ; Vol. 27, No. 3. pp. 253-257.
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