Lymphoepithelial cyst (LEC) of the pancreas: Cytomorphology and differential diagnosis on fine-needle aspiration (FNA)

Srinivas R. Mandavilli, John Port, Syed Z. Ali

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Lymphoepithelial cyst (LEC) of the pancreas is an extremely rare benign entity. We describe the cytopathologic findings of such a lesion in a 49-yr- old woman who was examined for epigastric pain. A trans-esophageal ultrasound-guided fine-needle aspiration of a pancreatic mass disclosed an intimate mixture of squamous epithelial cells and small, mature lymphocytes in a background of keratinaceous debris, anucleate squames, and multinucleated histiocytes. On histopathologic examination, a subsequent resection showed a multiloculated cystic lesions with a stratified squamous epithelial lining surrounded by well-formed lymphoid tissue, suggestive of LEC. The differential diagnosis includes other pancreatic pseudocysts, dermoid cyst, mucinous cystic neoplasms, adenosquamous carcinoma, and metastatic squamous cell carcinoma.

Original languageEnglish (US)
Pages (from-to)371-374
Number of pages4
JournalDiagnostic cytopathology
Volume20
Issue number6
DOIs
StatePublished - Jun 1999

Keywords

  • Cytopathology
  • Fine-needle aspiration
  • Lymphoepithelial cysts
  • Pancreas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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