Lymphocytic interstitial pneumonia: Thin-section CT findings in 22 patients

Takeshi Johkoh, Nestor L. Müller, Heather A. Pickford, Thomas E. Hartman, Kazuya Ichikado, Masanori Akira, Osamu Honda, Hironobu Nakamura

Research output: Contribution to journalArticle

231 Citations (Scopus)

Abstract

PURPOSE: To assess the thin-section computed tomographic (CT) findings of lymphocytic interstitial pneumonia. MATERIALS AND METHODS: The study included 22 patients (five men, 17 women; age range, 24-83 years; mean age, 50 years) with biopsy-proved lymphocytic interstitial pneumonia. The CT scans were obtained by using 1-3-mm collimation and reconstructed by using a high- spatial-frequency algorithm. RESULTS: The predominant abnormalities consisted of areas of ground-glass attenuation and poorly defined centrilobular nodules present in all 22 patients and subpleural small nodules seen in 19 patients. Other common findings included thickening of bronchovascular bundles (n = 19), interlobular septal thickening (n = 18), cystic airspaces (n = 15), and lymph node enlargement (n = 15). Less common findings included large nodules, emphysema, airspace consolidation, bronchiectasis, architectural distortion, honeycombing, and pleural thickening. CONCLUSION: Lymphocytic interstitial pneumonia is characterized by the presence of ground-glass attenuation, poorly defined centrilobular nodules, and thickening of the interstitium along the lymphatic vessels. Lymph node enlargement is more common than previously recognized; it was seen in 68% of patients.

Original languageEnglish (US)
Pages (from-to)567-572
Number of pages6
JournalRadiology
Volume212
Issue number2
StatePublished - Aug 1999

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Interstitial Lung Diseases
Glass
Lymph Nodes
Lymphatic Vessels
Bronchiectasis
Emphysema
Biopsy

Keywords

  • Acquired immunodeficiency syndrome (AIDS)
  • Castleman disease
  • Eye, diseases
  • Lung, CT
  • Pneumonitis, lymphocytic interstitial
  • Sjogren syndrome

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Johkoh, T., Müller, N. L., Pickford, H. A., Hartman, T. E., Ichikado, K., Akira, M., ... Nakamura, H. (1999). Lymphocytic interstitial pneumonia: Thin-section CT findings in 22 patients. Radiology, 212(2), 567-572.

Lymphocytic interstitial pneumonia : Thin-section CT findings in 22 patients. / Johkoh, Takeshi; Müller, Nestor L.; Pickford, Heather A.; Hartman, Thomas E.; Ichikado, Kazuya; Akira, Masanori; Honda, Osamu; Nakamura, Hironobu.

In: Radiology, Vol. 212, No. 2, 08.1999, p. 567-572.

Research output: Contribution to journalArticle

Johkoh, T, Müller, NL, Pickford, HA, Hartman, TE, Ichikado, K, Akira, M, Honda, O & Nakamura, H 1999, 'Lymphocytic interstitial pneumonia: Thin-section CT findings in 22 patients', Radiology, vol. 212, no. 2, pp. 567-572.
Johkoh T, Müller NL, Pickford HA, Hartman TE, Ichikado K, Akira M et al. Lymphocytic interstitial pneumonia: Thin-section CT findings in 22 patients. Radiology. 1999 Aug;212(2):567-572.
Johkoh, Takeshi ; Müller, Nestor L. ; Pickford, Heather A. ; Hartman, Thomas E. ; Ichikado, Kazuya ; Akira, Masanori ; Honda, Osamu ; Nakamura, Hironobu. / Lymphocytic interstitial pneumonia : Thin-section CT findings in 22 patients. In: Radiology. 1999 ; Vol. 212, No. 2. pp. 567-572.
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