Abstract
Three patients, one of whom has been previously reported, had erythematous papules and nodules of the face and upper part of the chest during cyclosporine therapy for inflammatory skin diseases. Histologic examination and DNA analysis (performed in two cases) revealed benign dermal lymphocytic infiltrates. In two cases proliferation of only T cells occurred. In the third case, both T and B cell populations were expanded and there was vacuolar degeneration of the basal layer of the epidermis and IgG, IgM, and C3 deposition along the dermoepidermal junction. These findings may be the result of cyclosporine-induced immune dysregulation. The lesions resolved in all patients after therapy was stopped.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1137-1141 |
| Number of pages | 5 |
| Journal | Journal of the American Academy of Dermatology |
| Volume | 23 |
| Issue number | 6 I |
| State | Published - 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
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Lymphocytic infiltrates of the skin in association with cyclosporine therapy. / Gupta, A. K.; Cooper, K. D.; Ellis, C. N.; Nickoloff, B. J.; Hanson, C. A.; Brown, M. D.; Voorhees, J. J.
In: Journal of the American Academy of Dermatology, Vol. 23, No. 6 I, 1990, p. 1137-1141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymphocytic infiltrates of the skin in association with cyclosporine therapy
AU - Gupta, A. K.
AU - Cooper, K. D.
AU - Ellis, C. N.
AU - Nickoloff, B. J.
AU - Hanson, C. A.
AU - Brown, M. D.
AU - Voorhees, J. J.
PY - 1990
Y1 - 1990
N2 - Three patients, one of whom has been previously reported, had erythematous papules and nodules of the face and upper part of the chest during cyclosporine therapy for inflammatory skin diseases. Histologic examination and DNA analysis (performed in two cases) revealed benign dermal lymphocytic infiltrates. In two cases proliferation of only T cells occurred. In the third case, both T and B cell populations were expanded and there was vacuolar degeneration of the basal layer of the epidermis and IgG, IgM, and C3 deposition along the dermoepidermal junction. These findings may be the result of cyclosporine-induced immune dysregulation. The lesions resolved in all patients after therapy was stopped.
AB - Three patients, one of whom has been previously reported, had erythematous papules and nodules of the face and upper part of the chest during cyclosporine therapy for inflammatory skin diseases. Histologic examination and DNA analysis (performed in two cases) revealed benign dermal lymphocytic infiltrates. In two cases proliferation of only T cells occurred. In the third case, both T and B cell populations were expanded and there was vacuolar degeneration of the basal layer of the epidermis and IgG, IgM, and C3 deposition along the dermoepidermal junction. These findings may be the result of cyclosporine-induced immune dysregulation. The lesions resolved in all patients after therapy was stopped.
UR - http://www.scopus.com/inward/record.url?scp=0025630697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025630697&partnerID=8YFLogxK
M3 - Article
C2 - 2273115
AN - SCOPUS:0025630697
VL - 23
SP - 1137
EP - 1141
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 6 I
ER -