Lymphocytic gastritis: Association with etiology and topology

Tsung Teh Wu, Stanley R. Hamilton

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Lymphocytic gastritis (LG) is an uncommon chronic gastritis characterized by lymphocytosis of foveolar and surface epithelium. Lymphocytic gastritis is associated with celiac disease, Helicobacter pylori (HP) gastritis, and varioliform gastritis, but its topology and severity with respect to the associated entities have not been studied in detail. Therefore, we studied 103 patients with LG classified according to the associated entities, including the distribution and severity of LG in the 70 patients from whom biopsy specimens of both antrum and body were available. In 84 patients (82%), a distinct associated entity was identified, including 39 with celiac disease, 30 with HP infection, 4 with varioliform gastritis, 2 each with inflammatory polyp, Crohn's disease, human immunodeficiency virus infection, lymphoma, and esophageal carcinoma, and 1 with lymphocytic gastroenterocolitis. Lymphocytic gastritis was found in 33% of patients with celiac disease and 4.1% of histopathologically defined HP gastritis. The severity of intraepithelial lymphocytosis was greater in antrum than in body in 83% (20 of 24) of LG associated with celiac disease, but in only 19% (4 of 21) of LG associated with HP infection (p < 0.00002). All four patients with varioliform gastritis had more severe involvement of body. Lymphocytic colitis was common (38%, 5 of 13) in celiac disease with LG. Our results indicate that lymphocytic gastritis most commonly occurs in celiac disease and HP infection, but rarely with other entities. The topology of LG can direct the clinical evaluation for associated disease.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume23
Issue number2
DOIs
StatePublished - Feb 1999
Externally publishedYes

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Gastritis
Celiac Disease
Helicobacter pylori
Helicobacter Infections
Lymphocytosis
Lymphocytic Colitis
Virus Diseases
Polyps
Crohn Disease

Keywords

  • Celiac disease
  • Helicobacter pylori
  • Lymphocytic colitis
  • Lymphocytic gastritis
  • Lymphocytic gastroenterocolitis
  • Varioliform gastritis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Lymphocytic gastritis : Association with etiology and topology. / Wu, Tsung Teh; Hamilton, Stanley R.

In: American Journal of Surgical Pathology, Vol. 23, No. 2, 02.1999, p. 153-158.

Research output: Contribution to journalArticle

Wu, Tsung Teh ; Hamilton, Stanley R. / Lymphocytic gastritis : Association with etiology and topology. In: American Journal of Surgical Pathology. 1999 ; Vol. 23, No. 2. pp. 153-158.
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