Lymphocyte‐Mediated Antibody‐Dependent Cytolysis: Role in Immune Hemolysis

B. S. Handwerger; N. E. Kay; S. D. Douglas

doi:10.1111/j.1423-0410.1978.tb02482.x

Lymphocyte‐Mediated Antibody‐Dependent Cytolysis: Role in Immune Hemolysis

B. S. Handwerger, N. E. Kay, S. D. Douglas

Hematology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Abstract. Peripheral blood lymphocytes obtained from normal volunteers were capable of lysing Rh(D)‐positive human erythrocytes in the presence of IgG anti‐Rh(D) antibodies. The percent cytotoxicity produced by peripheral blood lymphocytes was approximately equivalent to that produced by unfractionated peripheral blood mononuclear cells. Neither peripheral blood mononuclear cells nor peripheral blood lymphocytes lysed Rh(D)‐negative human erythrocytes in the presence of IgG anti‐Rh(D) antibody.

Original language	English (US)
Pages (from-to)	276-280
Number of pages	5
Journal	Vox Sanguinis
Volume	34
Issue number	5
DOIs	https://doi.org/10.1111/j.1423-0410.1978.tb02482.x
State	Published - May 1978

ASJC Scopus subject areas

Hematology

Access to Document

10.1111/j.1423-0410.1978.tb02482.x

Cite this

@article{d789f7508ed24de7b49036aa53c7ec16,

title = "Lymphocyte‐Mediated Antibody‐Dependent Cytolysis: Role in Immune Hemolysis",

abstract = "Abstract. Peripheral blood lymphocytes obtained from normal volunteers were capable of lysing Rh(D)‐positive human erythrocytes in the presence of IgG anti‐Rh(D) antibodies. The percent cytotoxicity produced by peripheral blood lymphocytes was approximately equivalent to that produced by unfractionated peripheral blood mononuclear cells. Neither peripheral blood mononuclear cells nor peripheral blood lymphocytes lysed Rh(D)‐negative human erythrocytes in the presence of IgG anti‐Rh(D) antibody.",

author = "Handwerger, {B. S.} and Kay, {N. E.} and Douglas, {S. D.}",

year = "1978",

month = may,

doi = "10.1111/j.1423-0410.1978.tb02482.x",

language = "English (US)",

volume = "34",

pages = "276--280",

journal = "Vox Sanguinis",

issn = "0042-9007",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Lymphocyte‐Mediated Antibody‐Dependent Cytolysis

T2 - Role in Immune Hemolysis

AU - Handwerger, B. S.

AU - Kay, N. E.

AU - Douglas, S. D.

PY - 1978/5

Y1 - 1978/5

N2 - Abstract. Peripheral blood lymphocytes obtained from normal volunteers were capable of lysing Rh(D)‐positive human erythrocytes in the presence of IgG anti‐Rh(D) antibodies. The percent cytotoxicity produced by peripheral blood lymphocytes was approximately equivalent to that produced by unfractionated peripheral blood mononuclear cells. Neither peripheral blood mononuclear cells nor peripheral blood lymphocytes lysed Rh(D)‐negative human erythrocytes in the presence of IgG anti‐Rh(D) antibody.

AB - Abstract. Peripheral blood lymphocytes obtained from normal volunteers were capable of lysing Rh(D)‐positive human erythrocytes in the presence of IgG anti‐Rh(D) antibodies. The percent cytotoxicity produced by peripheral blood lymphocytes was approximately equivalent to that produced by unfractionated peripheral blood mononuclear cells. Neither peripheral blood mononuclear cells nor peripheral blood lymphocytes lysed Rh(D)‐negative human erythrocytes in the presence of IgG anti‐Rh(D) antibody.

UR - http://www.scopus.com/inward/record.url?scp=0017840569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017840569&partnerID=8YFLogxK

U2 - 10.1111/j.1423-0410.1978.tb02482.x

DO - 10.1111/j.1423-0410.1978.tb02482.x

M3 - Article

C2 - 415434

AN - SCOPUS:0017840569

SN - 0042-9007

VL - 34

SP - 276

EP - 280

JO - Vox Sanguinis

JF - Vox Sanguinis

IS - 5

ER -

Lymphocyte‐Mediated Antibody‐Dependent Cytolysis: Role in Immune Hemolysis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this