Lymphocyte subsets in lung cancer

L. J. Wesselius, D. L. Wheaton, L. J. Manahan-Wahl, S. L. Sherard, S. A. Taylor, N. A. Abdou

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Altered cellular immune function has been demonstrated in patients with lung cancer, including decreased numbers of circulating lymphocytes and changes in the percentage of lymphocytes in various functional subsets. We quantitated lymphocyte subsets in 54 patients with lung cancer including patients with limited (stages 1 and 2) nonsmall cell lung cancer (NSCLC, n = 23), advanced (stage 3) NSCLC (n = 16), and small cell cancer (SCLC, n = 15). Serum albumin was decreased in 15 lung cancer patients, and lymphocyte subsets were separately evaluated in these patients. Lymphocyte populations in cancer patients were compared to those of nonsmokers and a smoking patient population. No difference from smokers was noted in patients with limited NSCLC. Patients with SCLC and advanced NSCLC had significantly decreased numbers of T-helper and T-suppressor cells (p < 0.05). Patients with lung cancer and hypoalbuminemia had the greatest decrease in number of circulating T-helper cells (p < 0.001). B-lymphocytes were also decreased in patients with advanced NSCLC and patients with hypoalbuminemia (p < 0.05). A decrease in population of T-lymphocytes subsets is frequent in patients with SCLC, advanced NSCLC, and lung cancer patients with hypoalbuminemia.

Original languageEnglish (US)
Pages (from-to)725-729
Number of pages5
JournalChest
Volume91
Issue number5
StatePublished - 1987
Externally publishedYes

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Lymphocyte Subsets
Lung Neoplasms
Hypoalbuminemia
Helper-Inducer T-Lymphocytes
Lymphocytes
Lymphocyte Count
Population Dynamics
T-Lymphocyte Subsets
Serum Albumin
Non-Small Cell Lung Carcinoma
Population
Neoplasms
B-Lymphocytes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Wesselius, L. J., Wheaton, D. L., Manahan-Wahl, L. J., Sherard, S. L., Taylor, S. A., & Abdou, N. A. (1987). Lymphocyte subsets in lung cancer. Chest, 91(5), 725-729.

Lymphocyte subsets in lung cancer. / Wesselius, L. J.; Wheaton, D. L.; Manahan-Wahl, L. J.; Sherard, S. L.; Taylor, S. A.; Abdou, N. A.

In: Chest, Vol. 91, No. 5, 1987, p. 725-729.

Research output: Contribution to journalArticle

Wesselius, LJ, Wheaton, DL, Manahan-Wahl, LJ, Sherard, SL, Taylor, SA & Abdou, NA 1987, 'Lymphocyte subsets in lung cancer', Chest, vol. 91, no. 5, pp. 725-729.
Wesselius LJ, Wheaton DL, Manahan-Wahl LJ, Sherard SL, Taylor SA, Abdou NA. Lymphocyte subsets in lung cancer. Chest. 1987;91(5):725-729.
Wesselius, L. J. ; Wheaton, D. L. ; Manahan-Wahl, L. J. ; Sherard, S. L. ; Taylor, S. A. ; Abdou, N. A. / Lymphocyte subsets in lung cancer. In: Chest. 1987 ; Vol. 91, No. 5. pp. 725-729.
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AU - Abdou, N. A.

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