Lymphoblastic transformation of myelodysplastic syndrome

J. L. Ascensao, Neil Elliot Kay, J. J. Wright, D. Arthur, B. Finkel, R. Rydell, M. E. Kaplan

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Acute myeloblastic leukemia occurs as a complication of myelodysplastic syndromes, but the appearance of an acute lymphoblastic leukemia (ALL) has only been reported once. We describe a case in which lymphoblastic transformation occurred in the setting of a dysmyelopoietic syndrome. This leukemia was characterized by lymphoid morphology, terminal deoxynucleotidyl transferase (TdT) positivity, cytogenetic abnormalities, and immunoglobulin gene rearrangements. The patient responded to conventional therapy for this leukemia (vincristine and prednisolone). Our case supports the hypothesis of a common lymphohemopoietic progenitor and suggests that in vitro tests may help identify a subset of these patients and be important in selecting appropriate therapy.

Original languageEnglish (US)
Pages (from-to)431-434
Number of pages4
JournalAmerican Journal of Hematology
Volume22
Issue number4
StatePublished - 1986
Externally publishedYes

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Myelodysplastic Syndromes
Leukemia
Immunoglobulin Genes
DNA Nucleotidylexotransferase
Gene Rearrangement
Vincristine
Prednisolone
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Chromosome Aberrations
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Hematology

Cite this

Ascensao, J. L., Kay, N. E., Wright, J. J., Arthur, D., Finkel, B., Rydell, R., & Kaplan, M. E. (1986). Lymphoblastic transformation of myelodysplastic syndrome. American Journal of Hematology, 22(4), 431-434.

Lymphoblastic transformation of myelodysplastic syndrome. / Ascensao, J. L.; Kay, Neil Elliot; Wright, J. J.; Arthur, D.; Finkel, B.; Rydell, R.; Kaplan, M. E.

In: American Journal of Hematology, Vol. 22, No. 4, 1986, p. 431-434.

Research output: Contribution to journalArticle

Ascensao, JL, Kay, NE, Wright, JJ, Arthur, D, Finkel, B, Rydell, R & Kaplan, ME 1986, 'Lymphoblastic transformation of myelodysplastic syndrome', American Journal of Hematology, vol. 22, no. 4, pp. 431-434.
Ascensao JL, Kay NE, Wright JJ, Arthur D, Finkel B, Rydell R et al. Lymphoblastic transformation of myelodysplastic syndrome. American Journal of Hematology. 1986;22(4):431-434.
Ascensao, J. L. ; Kay, Neil Elliot ; Wright, J. J. ; Arthur, D. ; Finkel, B. ; Rydell, R. ; Kaplan, M. E. / Lymphoblastic transformation of myelodysplastic syndrome. In: American Journal of Hematology. 1986 ; Vol. 22, No. 4. pp. 431-434.
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