LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome

Medicine & Life Sciences

• 2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)-pyrimidin-4-yl)phenyl)propionic acid 100%
• Tryptophan Hydroxylase 56%
• Irritable Bowel Syndrome 46%
• Serotonin 35%
• Hydroxyindoleacetic Acid 22%
• Phase II Clinical Trials 7%
• Clinical Trials, Phase I 7%
• Therapeutics 6%
• Jejunum 6%
• Ileum 5%
• Duodenum 5%
• Diarrhea 4%
• Healthy Volunteers 3%
• Clinical Trials 3%
• Safety 3%
• Brain 2%
• Pharmaceutical Preparations 2%

Chemical Compounds

• Tryptophan 37%
• Dose 31%
• Marker 17%
• Safety 17%
• Pharmacological Metabolism 15%
• Pharmaceutical 14%
• Acid 7%