LV pressure-volume area and oxygen consumption: Evaluation in intact dog by fast CT

N. Chung, X. Wu, K. R. Bailey, E. L. Ritman

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The relationship between left ventricular (LV) myocardial oxygen consumption (MV̇O2) and LV systolic pressure-volume area (PVA) was investigated in anesthetized closed-chest dogs with intact reflexes and subsequently with β-adrenergic blockade, with or without simultaneous muscarinic blockade. LV chamber volumes were measured using a fast computerized tomography (CT) scanner (dynamic spatial reconstructor, DSR) at 33-ms intervals. Myocardial blood flow was measured from the DSR scans of aortic root angiograms. With intact reflexes, LV MV̇O2 (Y) related to PVA (X) value as Y = (4.28 ± 1.81)X + (1.94 ± 6.0) (n = 24) (mJ·g-1·cycle-1). With β-adrenergic blockade, LV MV̇O2 (Y) related to PVA (X) value as Y = (4.24 ± 1.03) X - (6.43 ± 6.5), (n = 9) (mJ·g-1·cycle-1). With β-adrenergic and muscarinic blockade, LV MV̇O2 (Y) related to PVA (X) value as Y = (2.84 ± 1.72)X + (3.51 ± 5.15), (n = 13) (mJ·g-1·cycle-1). The slopes of these regressions are higher than the slopes demonstrated by others in isolated ventricles but very similar to those demonstrated in open-chest dogs.

Original languageEnglish (US)
Pages (from-to)H1208-H1215
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume258
Issue number4 27-4
DOIs
StatePublished - 1990

Keywords

  • X-ray computerized tomography
  • angiography
  • left ventricular chamber volume

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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