LV oxygen consumption and pressure-volume area: Role of norepinephrine and verapamil

N. Chung, X. Wu, E. L. Ritman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of norepinephrine or verapamil on the relationship of left ventricular (LV) myocardial oxygen consumption (MV̇O2) and systolic pressure-volume area (PVA) was investigated in hearts within the never-opened thorax of dogs with blocked baroreceptor reflex. LV chamber volumes and myocardial blood flow were measured using a fast computed tomography scanner. At 10 μg/min delivery rate of norepinephrine, MV̇O2 (mJ·g-1·cycle-1) equals (2.30 ± 0.48) PVA + (20.60 ± 4.24) (n = 11; 1 mJ·g-1·cycle-1 is equivalent to 0.563 ml O2·100 g-1·min-1 at 112 beats/min). With verapamil infusion, MV̇O2 equals (2.57 ± 1.33)PVA + (10.73 ± 3.16) (n = 17). The regression slopes did not differ (P > 0.25) for any of the conditions. At comparable PVA values the norepinephrine group showed an increase of MV̇O2 compared with the prenorepinephrine baseline state (P < 0.01), and the verapamil group showed a reduction of MV̇O2 compared with the preverapamil baseline state (P < 0.05). We conclude that the MV̇O2 to LVPVA relationship in the in situ heart, within the never-opened thorax, conveys that the oxygen-wasting effect of catecholamines is quantifiable using the shift in this relationship.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume261
Issue number1 30-1
StatePublished - 1991

Fingerprint

Verapamil
Oxygen Consumption
Norepinephrine
Pressure
Thorax
X-Ray Computed Tomography Scanners
Baroreflex
Blood Volume
Catecholamines
Dogs
Oxygen
Blood Pressure

Keywords

  • Angiography
  • Calcium channel blocker
  • Catecholamines
  • Fast computed tomography
  • Left ventricular chamber volume

ASJC Scopus subject areas

  • Physiology

Cite this

LV oxygen consumption and pressure-volume area : Role of norepinephrine and verapamil. / Chung, N.; Wu, X.; Ritman, E. L.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 261, No. 1 30-1, 1991.

Research output: Contribution to journalArticle

@article{42c624e655e9407e956e906452dbd7bb,
title = "LV oxygen consumption and pressure-volume area: Role of norepinephrine and verapamil",
abstract = "The effect of norepinephrine or verapamil on the relationship of left ventricular (LV) myocardial oxygen consumption (MV̇O2) and systolic pressure-volume area (PVA) was investigated in hearts within the never-opened thorax of dogs with blocked baroreceptor reflex. LV chamber volumes and myocardial blood flow were measured using a fast computed tomography scanner. At 10 μg/min delivery rate of norepinephrine, MV̇O2 (mJ·g-1·cycle-1) equals (2.30 ± 0.48) PVA + (20.60 ± 4.24) (n = 11; 1 mJ·g-1·cycle-1 is equivalent to 0.563 ml O2·100 g-1·min-1 at 112 beats/min). With verapamil infusion, MV̇O2 equals (2.57 ± 1.33)PVA + (10.73 ± 3.16) (n = 17). The regression slopes did not differ (P > 0.25) for any of the conditions. At comparable PVA values the norepinephrine group showed an increase of MV̇O2 compared with the prenorepinephrine baseline state (P < 0.01), and the verapamil group showed a reduction of MV̇O2 compared with the preverapamil baseline state (P < 0.05). We conclude that the MV̇O2 to LVPVA relationship in the in situ heart, within the never-opened thorax, conveys that the oxygen-wasting effect of catecholamines is quantifiable using the shift in this relationship.",
keywords = "Angiography, Calcium channel blocker, Catecholamines, Fast computed tomography, Left ventricular chamber volume",
author = "N. Chung and X. Wu and Ritman, {E. L.}",
year = "1991",
language = "English (US)",
volume = "261",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "1 30-1",

}

TY - JOUR

T1 - LV oxygen consumption and pressure-volume area

T2 - Role of norepinephrine and verapamil

AU - Chung, N.

AU - Wu, X.

AU - Ritman, E. L.

PY - 1991

Y1 - 1991

N2 - The effect of norepinephrine or verapamil on the relationship of left ventricular (LV) myocardial oxygen consumption (MV̇O2) and systolic pressure-volume area (PVA) was investigated in hearts within the never-opened thorax of dogs with blocked baroreceptor reflex. LV chamber volumes and myocardial blood flow were measured using a fast computed tomography scanner. At 10 μg/min delivery rate of norepinephrine, MV̇O2 (mJ·g-1·cycle-1) equals (2.30 ± 0.48) PVA + (20.60 ± 4.24) (n = 11; 1 mJ·g-1·cycle-1 is equivalent to 0.563 ml O2·100 g-1·min-1 at 112 beats/min). With verapamil infusion, MV̇O2 equals (2.57 ± 1.33)PVA + (10.73 ± 3.16) (n = 17). The regression slopes did not differ (P > 0.25) for any of the conditions. At comparable PVA values the norepinephrine group showed an increase of MV̇O2 compared with the prenorepinephrine baseline state (P < 0.01), and the verapamil group showed a reduction of MV̇O2 compared with the preverapamil baseline state (P < 0.05). We conclude that the MV̇O2 to LVPVA relationship in the in situ heart, within the never-opened thorax, conveys that the oxygen-wasting effect of catecholamines is quantifiable using the shift in this relationship.

AB - The effect of norepinephrine or verapamil on the relationship of left ventricular (LV) myocardial oxygen consumption (MV̇O2) and systolic pressure-volume area (PVA) was investigated in hearts within the never-opened thorax of dogs with blocked baroreceptor reflex. LV chamber volumes and myocardial blood flow were measured using a fast computed tomography scanner. At 10 μg/min delivery rate of norepinephrine, MV̇O2 (mJ·g-1·cycle-1) equals (2.30 ± 0.48) PVA + (20.60 ± 4.24) (n = 11; 1 mJ·g-1·cycle-1 is equivalent to 0.563 ml O2·100 g-1·min-1 at 112 beats/min). With verapamil infusion, MV̇O2 equals (2.57 ± 1.33)PVA + (10.73 ± 3.16) (n = 17). The regression slopes did not differ (P > 0.25) for any of the conditions. At comparable PVA values the norepinephrine group showed an increase of MV̇O2 compared with the prenorepinephrine baseline state (P < 0.01), and the verapamil group showed a reduction of MV̇O2 compared with the preverapamil baseline state (P < 0.05). We conclude that the MV̇O2 to LVPVA relationship in the in situ heart, within the never-opened thorax, conveys that the oxygen-wasting effect of catecholamines is quantifiable using the shift in this relationship.

KW - Angiography

KW - Calcium channel blocker

KW - Catecholamines

KW - Fast computed tomography

KW - Left ventricular chamber volume

UR - http://www.scopus.com/inward/record.url?scp=0025895701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025895701&partnerID=8YFLogxK

M3 - Article

C2 - 1858933

AN - SCOPUS:0025895701

VL - 261

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 1 30-1

ER -