Lupus anticoagulant associated with transient severe factor X deficiency: A report of two patients presenting with major bleeding complications

Aneel A. Ashrani, Agnes Aysola, Hani Al-Khatib, William L. Nichols, Nigel S. Key

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Acquired factor X (FX) deficiency is rare, but has been reported in diverse disease states, including systemic amyloidosis and respiratory infections. FX deficiency associated with lupus anticoagulant (LA) and a bleeding diathesis has not been previously reported. We report two patients both of whom presented with a severe bleeding diathesis after a preceding respiratory infection due to isolated FX deficiency associated with a LA. The FX deficiency and LA were transient. We conclude that patients with LA may rarely present with severe acquired FX deficiency. This may be another mechanism whereby patients with antiphospholipid antibodies present with bleeding complications.

Original languageEnglish (US)
Pages (from-to)639-642
Number of pages4
JournalBritish journal of haematology
Volume121
Issue number4
DOIs
StatePublished - May 1 2003

Keywords

  • Acquired factor X deficiency
  • Bleeding disorder/bleeding diathesis
  • Lupus anticoagulant
  • Respiratory infection

ASJC Scopus subject areas

  • Hematology

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