Lung Ultrasound Surface Wave Elastography for Assessing Patients with Pulmonary Edema

Xiaoming Zhang, Brandon M. Wiley, Boran Zhou, Govind Pandompatam, Hilal Olgun Kucuk, Jinling Zhou

Research output: Contribution to journalArticlepeer-review

Abstract

Ultrasound insonation of lungs that are dense with extravascular lung water (EVLW) produces characteristic reverberation artifacts termed B-lines. The number of B-lines present demonstrates reasonable correlation to the amount of EVLW. However, analysis of B-line artifacts generated by this modality is semi-quantitative relying on visual interpretation, and as a result, can be subject to inter-observer variability. The purpose of this study was to translate the use of a novel, quantitative lung ultrasound surface wave elastography technique (LUSWE) into the bedside assessment of pulmonary edema in patients admitted with acute congestive heart failure. B-mode lung ultrasound and LUSWE assessment of the lungs were performed using anterior and lateral intercostal spaces in the supine patient. 14 patients were evaluated at admission with reassessment performed 1-2 days after initiation of diuretic therapy. Each exam recorded the total lung B-lines, lung surface wave speeds (at 100, 150, and 200 Hz) and net fluid balance. The patient cohort experienced effective diuresis (average net fluid balance of negative 2.1 liters) with corresponding decrease in pulmonary edema visualized by B-mode ultrasound (average decrease of 13 B-Lines). In addition, LUSWE demonstrated a statistically significant reduction in the magnitude of wave speed from admission to follow-up. The reduction in lung surface wave speed suggests a decrease in lung stiffness (decreased elasticity) mediated by successful reduction of pulmonary edema. In summary, LUSWE is a noninvasive technique for quantifying elastic properties of superficial lung tissue that may prove useful as a diagnostic test, performed at the bedside, for the quantitative assessment of pulmonary edema.

Original languageEnglish (US)
JournalIEEE Transactions on Biomedical Engineering
DOIs
StateAccepted/In press - 2021

Keywords

  • B-line
  • Biomedical measurement
  • Extraterrestrial measurements
  • Frequency measurement
  • Lung
  • Surface waves
  • Ultrasonic imaging
  • Ultrasonic variables measurement
  • extravascular lung water (EVLW)
  • heart failure
  • lung ultrasound
  • lung ultrasound surface wave elastography (LUSWE)
  • pulmonary edema
  • wave speed

ASJC Scopus subject areas

  • Biomedical Engineering

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