TY - JOUR
T1 - Lung Ultrasound Surface Wave Elastography
T2 - A Pilot Clinical Study
AU - Zhang, Xiaoming
AU - Osborn, Thomas
AU - Zhou, Boran
AU - Meixner, Duane
AU - Kinnick, Randall R.
AU - Bartholmai, Brian
AU - Greenleaf, James F.
AU - Kalra, Sanjay
N1 - Funding Information:
Manuscript received March 9, 2017; accepted May 22, 2017. Date of publication June 2, 2017; date of current version August 28, 2017. This work was supported by the National Heart, Lung, and Blood Institute under Grant NIH R01HL125234. (Corresponding author: Xiaoming Zhang.) X. Zhang is with the Department of Radiology, Mayo Clinic, Rochester, MN 55905 USA and also with the Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905 USA (e-mail: zhang.xiaoming@mayo.edu). T. Osborn is with the Department of Rheumatology, Mayo Clinic, Rochester, MN 55905 USA. B. Zhou, D. Meixner, and B. Bartholmai are with the Department of Radiology, Mayo Clinic, Rochester, MN 55905 USA. R. R. Kinnick and J. F. Greenleaf are with the Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905 USA. S. Kalra is with the Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905 USA. Digital Object Identifier 10.1109/TUFFC.2017.2707981
Publisher Copyright:
© 1986-2012 IEEE.
PY - 2017/9
Y1 - 2017/9
N2 - A lung ultrasound surface wave elastography (LUSWE) technique is developed to measure superficial lung tissue elastic properties. The purpose of this paper was to translate LUSWE into clinical studies for assessing patients with interstitial lung disease (ILD) and present the pilot data from lung measurements on 10 healthy subjects and 10 patients with ILD. ILD includes multiple lung disorders in which the lung tissue is distorted and stiffened by tissue fibrosis. Chest radiography and computed tomography are the most commonly used techniques for assessing lung disease, but they are associated with radiation and cannot directly measure lung elastic properties. LUSWE provides a noninvasive and nonionizing technique to measure the elastic properties of superficial lung tissue. LUSWE was used to measure regions of both lungs through six intercostal spaces for patients and healthy subjects. The data are presented as wave speed at 100, 150, and 200 Hz at the six intercostal spaces. As an example, the surface wave speeds are, respectively, 1.88 ± 0.11 m/s at 100 Hz, 2.74 ± 0.26 m/s at 150 Hz, and 3.62 ± 0.13 m/s at 200 Hz for a healthy subject in the upper right lung; this is in comparison to measurements from an ILD patient of 3.3 ± 0.37 m/s at 100 Hz, 4.38 ± 0.33 m/s at 150 Hz, and 5.24 ± 0.44 m/s at 200 Hz in the same lung space. Significant differences in wave speed between healthy subjects and ILD patients were found. LUSWE is a safe and noninvasive technique which may be useful for assessing ILD.
AB - A lung ultrasound surface wave elastography (LUSWE) technique is developed to measure superficial lung tissue elastic properties. The purpose of this paper was to translate LUSWE into clinical studies for assessing patients with interstitial lung disease (ILD) and present the pilot data from lung measurements on 10 healthy subjects and 10 patients with ILD. ILD includes multiple lung disorders in which the lung tissue is distorted and stiffened by tissue fibrosis. Chest radiography and computed tomography are the most commonly used techniques for assessing lung disease, but they are associated with radiation and cannot directly measure lung elastic properties. LUSWE provides a noninvasive and nonionizing technique to measure the elastic properties of superficial lung tissue. LUSWE was used to measure regions of both lungs through six intercostal spaces for patients and healthy subjects. The data are presented as wave speed at 100, 150, and 200 Hz at the six intercostal spaces. As an example, the surface wave speeds are, respectively, 1.88 ± 0.11 m/s at 100 Hz, 2.74 ± 0.26 m/s at 150 Hz, and 3.62 ± 0.13 m/s at 200 Hz for a healthy subject in the upper right lung; this is in comparison to measurements from an ILD patient of 3.3 ± 0.37 m/s at 100 Hz, 4.38 ± 0.33 m/s at 150 Hz, and 5.24 ± 0.44 m/s at 200 Hz in the same lung space. Significant differences in wave speed between healthy subjects and ILD patients were found. LUSWE is a safe and noninvasive technique which may be useful for assessing ILD.
KW - Interstitial lung disease (ILD)
KW - lung
KW - surface wave elastography (SWE)
KW - ultrasound
KW - wave speed
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U2 - 10.1109/TUFFC.2017.2707981
DO - 10.1109/TUFFC.2017.2707981
M3 - Article
C2 - 28866480
AN - SCOPUS:85029089726
VL - 64
SP - 1298
EP - 1304
JO - IRE Transactions on Ultrasonic Engineering
JF - IRE Transactions on Ultrasonic Engineering
SN - 0885-3010
IS - 9
M1 - 7938345
ER -