Lung nodules: Dual-kilovolt peak analysis with CT - Multicenter study

Stephen J. Swensen, Keiji Yamashita, Cynthia H McCollough, Robert W. Viggiano, David Eric Midthun, Edward F. Patz, John R. Muhm, Amy L. Weaver

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

PURPOSE: To test the following hypothesis: The greater the increase in the mean computed tomographic (CT) number of a radiologically indeterminate lung nodule from the CT number on a 140-kVp CT image to that on an 80-kVp CT image, the more likely the nodule is benign (ie, contains calcium). MATERIALS AND METHODS: Two hundred forty indeterminate lung nodules were prospectively studied at four institutions: Mayo Clinic Scottsdale, Ariz (n = 160); Mayo Clinic Rochester, Minn (n = 50); Shiga Health Insurance Hospital, Otsu, Japan (n = 25); and Duke University Medical Center, Durham, NC (n = 5). Of the 240 nodules, 157 met the entrance criteria for this study and had a diagnosis. All nodules included were solid, 5-40-mm diameter, relatively spherical, homogeneous, and without visible evidence of calcification or fat. Each nodule was evaluated by using 3-mm-collimation, nonenhanced CT scans with both 140- and 80-kVp x-ray beams. RESULTS: There were 86 (55%) benign and 71 (45%) malignant nodules. The median increase in the nodule mean CT number from the CT number on 140-kVp images to that on 80-kVp images was 2 HU for benign nodules and 3 HU for malignant nodules. This difference was not statistically significant. The area under the receiver operating characteristic curve was 0.505. CONCLUSION: Dual-kilovolt peak analysis with current CT technology does not appear to be helpful in the identification of benign lung nodules.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalRadiology
Volume214
Issue number1
StatePublished - 2000

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Multicenter Studies
Lung
Health Insurance
ROC Curve
Japan
Fats
X-Rays
Calcium
Technology

Keywords

  • Lung neoplasms, CT
  • Lung neoplasms, diagnosis
  • Lung, CT
  • Lung, nodule

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Swensen, S. J., Yamashita, K., McCollough, C. H., Viggiano, R. W., Midthun, D. E., Patz, E. F., ... Weaver, A. L. (2000). Lung nodules: Dual-kilovolt peak analysis with CT - Multicenter study. Radiology, 214(1), 81-85.

Lung nodules : Dual-kilovolt peak analysis with CT - Multicenter study. / Swensen, Stephen J.; Yamashita, Keiji; McCollough, Cynthia H; Viggiano, Robert W.; Midthun, David Eric; Patz, Edward F.; Muhm, John R.; Weaver, Amy L.

In: Radiology, Vol. 214, No. 1, 2000, p. 81-85.

Research output: Contribution to journalArticle

Swensen, SJ, Yamashita, K, McCollough, CH, Viggiano, RW, Midthun, DE, Patz, EF, Muhm, JR & Weaver, AL 2000, 'Lung nodules: Dual-kilovolt peak analysis with CT - Multicenter study', Radiology, vol. 214, no. 1, pp. 81-85.
Swensen SJ, Yamashita K, McCollough CH, Viggiano RW, Midthun DE, Patz EF et al. Lung nodules: Dual-kilovolt peak analysis with CT - Multicenter study. Radiology. 2000;214(1):81-85.
Swensen, Stephen J. ; Yamashita, Keiji ; McCollough, Cynthia H ; Viggiano, Robert W. ; Midthun, David Eric ; Patz, Edward F. ; Muhm, John R. ; Weaver, Amy L. / Lung nodules : Dual-kilovolt peak analysis with CT - Multicenter study. In: Radiology. 2000 ; Vol. 214, No. 1. pp. 81-85.
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AB - PURPOSE: To test the following hypothesis: The greater the increase in the mean computed tomographic (CT) number of a radiologically indeterminate lung nodule from the CT number on a 140-kVp CT image to that on an 80-kVp CT image, the more likely the nodule is benign (ie, contains calcium). MATERIALS AND METHODS: Two hundred forty indeterminate lung nodules were prospectively studied at four institutions: Mayo Clinic Scottsdale, Ariz (n = 160); Mayo Clinic Rochester, Minn (n = 50); Shiga Health Insurance Hospital, Otsu, Japan (n = 25); and Duke University Medical Center, Durham, NC (n = 5). Of the 240 nodules, 157 met the entrance criteria for this study and had a diagnosis. All nodules included were solid, 5-40-mm diameter, relatively spherical, homogeneous, and without visible evidence of calcification or fat. Each nodule was evaluated by using 3-mm-collimation, nonenhanced CT scans with both 140- and 80-kVp x-ray beams. RESULTS: There were 86 (55%) benign and 71 (45%) malignant nodules. The median increase in the nodule mean CT number from the CT number on 140-kVp images to that on 80-kVp images was 2 HU for benign nodules and 3 HU for malignant nodules. This difference was not statistically significant. The area under the receiver operating characteristic curve was 0.505. CONCLUSION: Dual-kilovolt peak analysis with current CT technology does not appear to be helpful in the identification of benign lung nodules.

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