Lung involvement in ANCA-associated vasculitis

Goethe Sacoto, Sara Boukhlal, Ulrich Specks, Luis Felipe Flores-Suárez, Divi Cornec

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

Lung involvement is one of the most common clinical features in ANCA-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). In this review, we detail the five main presentations of pulmonary involvement in AAV: necrotizing granulomatous inflammation, tracheobronchial inflammation, pulmonary capillaritis, interstitial lung disease (ILD) and asthma with their clinical, radiological and therapeutic characteristics. The prevalence of these manifestations is variable according to the subtype of AAV, necrotizing granulomatous inflammation and tracheobronchial inflammation being defining features of GPA whereas ILD is primarily seen in patients with MPA, especially in association with ANCA directed against myeloperoxydase (MPO-ANCA), and asthma is characteristic of EGPA. Despite recent progresses in the diagnosis and management of these conditions, several questions remain and are discussed here, including local treatments for subglottic stenosis, the uncertain efficacy of plasma exchanges for alveolar hemorrhage, the potential role of antifibrotic agents in ILD associated with MPA, and the use of novel anti-IL-5 strategies in EGPA.

Original languageEnglish (US)
Article number104039
JournalPresse Medicale
Volume49
Issue number3
DOIs
StatePublished - Oct 2020

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Lung involvement in ANCA-associated vasculitis'. Together they form a unique fingerprint.

  • Cite this

    Sacoto, G., Boukhlal, S., Specks, U., Flores-Suárez, L. F., & Cornec, D. (2020). Lung involvement in ANCA-associated vasculitis. Presse Medicale, 49(3), [104039]. https://doi.org/10.1016/j.lpm.2020.104039