Lung cancer: Developmental networks gone awry?

Jie Dong, Thomas Kislinger, Igor Jurisica, Dennis A. Wigle

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

High-throughput genomic data for both lung development and lung cancer continue to accumulate. Significant molecular intersection between these two processes has been hypothesized due to overlap in phenotypes and genomic variation. Examining the network biology of both cancer and development of the lung may shed functional light on the individual signaling modules involved. Stem cell biology may explain a portion of this network intersection and consequently studying lung organogenesis may have relevance for understanding lung cancer. This review summarizes our understanding of the potential overlapping mechanisms involved in lung development and lung tumorigenesis.

Original languageEnglish (US)
Pages (from-to)312-318
Number of pages7
JournalCancer Biology and Therapy
Volume8
Issue number4
DOIs
StatePublished - Feb 15 2009

Keywords

  • Gene expression profile
  • Lung cancer
  • Lung development
  • Network biology
  • Signaling pathway
  • Stem cell

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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