Lung cancer and chronic obstructive pulmonary disease: From a clinical perspective

Jie Dai, Ping Yang, Angela Cox, Gening Jiang

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Chronic obstructive pulmonary disease (COPD) and lung cancer are devastating pulmonary diseases that commonly coexist and present a number of clinical challenges. COPD confers a higher risk for lung cancer development, but available chemopreventive measures remain rudimentary. Current studies have shown a marked benefit of cancer screening in the COPD population, although challenges remain, including the common underdiagnosis of COPD. COPD-associated lung cancer presents distinct clinical features. Treatment for lung cancer coexisting with COPD is challenging as COPD may increase postoperative morbidities and decrease survival. In this review, we outline current progress in the understanding of the clinical association between COPD and lung cancer, and suggest possible cancer prevention strategies in this patient population.

Original languageEnglish (US)
Pages (from-to)18513-18524
Number of pages12
JournalOncotarget
Volume8
Issue number11
DOIs
StatePublished - 2017

Keywords

  • Association
  • Chronic obstructive pulmonary disease
  • Lung cancer

ASJC Scopus subject areas

  • Oncology

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