LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth

Martin E Fernandez-Zapico, Meghan M. Kozub, Ryan M. Carr, Gwen L. Lomberk

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Histone-modifying enzymes play a critical role in chromatin remodeling and are essential for influencing several genome processes such as gene expression and DNA repair, replication, and recombination. The discovery of lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, dramatically revolutionized research in the field of epigenetics. LSD1 plays a pivotal role in a wide range of biological operations, including development, cellular differentiation, embryonic pluripotency, and disease (for example, cancer). This mini-review focuses on the role of LSD1 in chromatin regulatory complexes, its involvement in epigenetic changes throughout development, and its importance in physiological and pathological processes.

Original languageEnglish (US)
Article number2016
JournalF1000Research
Volume6
DOIs
StatePublished - Jan 1 2017

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Keywords

  • Cancer
  • Epigenetics
  • Histone demethylation
  • KDM1a
  • LSD1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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