LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth

Martin E. Fernandez-Zapico; Meghan M. Kozub; Ryan M. Carr; Gwen L. Lomberk

doi:10.12688/f1000research.12169.1

LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth

Martin E. Fernandez-Zapico, Meghan M. Kozub, Ryan M. Carr, Gwen L. Lomberk

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Histone-modifying enzymes play a critical role in chromatin remodeling and are essential for influencing several genome processes such as gene expression and DNA repair, replication, and recombination. The discovery of lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, dramatically revolutionized research in the field of epigenetics. LSD1 plays a pivotal role in a wide range of biological operations, including development, cellular differentiation, embryonic pluripotency, and disease (for example, cancer). This mini-review focuses on the role of LSD1 in chromatin regulatory complexes, its involvement in epigenetic changes throughout development, and its importance in physiological and pathological processes.

Original language	English (US)
Article number	2016
Journal	F1000Research
Volume	6
DOIs	https://doi.org/10.12688/f1000research.12169.1
State	Published - 2017

Keywords

Cancer
Epigenetics
Histone demethylation
KDM1a
LSD1

ASJC Scopus subject areas

General Immunology and Microbiology
General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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title = "LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth",

abstract = "Histone-modifying enzymes play a critical role in chromatin remodeling and are essential for influencing several genome processes such as gene expression and DNA repair, replication, and recombination. The discovery of lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, dramatically revolutionized research in the field of epigenetics. LSD1 plays a pivotal role in a wide range of biological operations, including development, cellular differentiation, embryonic pluripotency, and disease (for example, cancer). This mini-review focuses on the role of LSD1 in chromatin regulatory complexes, its involvement in epigenetic changes throughout development, and its importance in physiological and pathological processes.",

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T1 - LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth

AU - Fernandez-Zapico, Martin E.

AU - Kozub, Meghan M.

AU - Carr, Ryan M.

AU - Lomberk, Gwen L.

PY - 2017

Y1 - 2017

N2 - Histone-modifying enzymes play a critical role in chromatin remodeling and are essential for influencing several genome processes such as gene expression and DNA repair, replication, and recombination. The discovery of lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, dramatically revolutionized research in the field of epigenetics. LSD1 plays a pivotal role in a wide range of biological operations, including development, cellular differentiation, embryonic pluripotency, and disease (for example, cancer). This mini-review focuses on the role of LSD1 in chromatin regulatory complexes, its involvement in epigenetic changes throughout development, and its importance in physiological and pathological processes.

AB - Histone-modifying enzymes play a critical role in chromatin remodeling and are essential for influencing several genome processes such as gene expression and DNA repair, replication, and recombination. The discovery of lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, dramatically revolutionized research in the field of epigenetics. LSD1 plays a pivotal role in a wide range of biological operations, including development, cellular differentiation, embryonic pluripotency, and disease (for example, cancer). This mini-review focuses on the role of LSD1 in chromatin regulatory complexes, its involvement in epigenetic changes throughout development, and its importance in physiological and pathological processes.

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KW - Epigenetics

KW - Histone demethylation

KW - KDM1a

KW - LSD1

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LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth

Abstract

Keywords

ASJC Scopus subject areas

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