LRRK2 variation and Parkinson's disease in African Americans

Owen A. Ross, Greggory J. Wilhoite, Justin A. Bacon, Alexandra Soto-Ortolaza, Jennifer Kachergus, Stephanie A. Cobb, Andreas Puschmann, Carles Vilariño-Güell, Matthew J. Farrer, Neill Graff-Radford, James F. Meschia, Zbigniew K. Wszolek

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The global impact of LRRK2 mutations is yet to be realized with a lack of studies in specific ethnic groups, including those of Asian and African descent. Herein, we investigated the frequency of common LRRK2 variants by complete exon sequencing in a series of publicly available African American Parkinson's disease patients. Our study identified three novel synonymous exonic variants and 13 known coding variations; however, there did not appear to be any frequent (>5%) pathogenic mutations. Given the ethnic-specific LRRK2 variation previously identified in PD further studies in under-represented populations are warranted.

Original languageEnglish (US)
Pages (from-to)1973-1976
Number of pages4
JournalMovement Disorders
Volume25
Issue number12
DOIs
StatePublished - Sep 15 2010

Keywords

  • Genetics
  • Leucine-rich repeat kinase 2
  • Parkinsonism

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Ross, O. A., Wilhoite, G. J., Bacon, J. A., Soto-Ortolaza, A., Kachergus, J., Cobb, S. A., Puschmann, A., Vilariño-Güell, C., Farrer, M. J., Graff-Radford, N., Meschia, J. F., & Wszolek, Z. K. (2010). LRRK2 variation and Parkinson's disease in African Americans. Movement Disorders, 25(12), 1973-1976. https://doi.org/10.1002/mds.23163