Abstract
The global impact of LRRK2 mutations is yet to be realized with a lack of studies in specific ethnic groups, including those of Asian and African descent. Herein, we investigated the frequency of common LRRK2 variants by complete exon sequencing in a series of publicly available African American Parkinson's disease patients. Our study identified three novel synonymous exonic variants and 13 known coding variations; however, there did not appear to be any frequent (>5%) pathogenic mutations. Given the ethnic-specific LRRK2 variation previously identified in PD further studies in under-represented populations are warranted.
Original language | English (US) |
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Pages (from-to) | 1973-1976 |
Number of pages | 4 |
Journal | Movement Disorders |
Volume | 25 |
Issue number | 12 |
DOIs | |
State | Published - Sep 15 2010 |
Keywords
- Genetics
- Leucine-rich repeat kinase 2
- Parkinsonism
ASJC Scopus subject areas
- Neurology
- Clinical Neurology