LRRK2 mutations are not common in Alzheimer's disease

Mathias Toft, Sigrid Botne Sando, Stacey Melquist, Owen A. Ross, Linda R. White, Jan O. Aasly, Matthew J. Farrer

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The development of common age-related neurodegenerative disorders as Parkinson's disease and Alzheimer's disease (AD) are influenced by genetic factors. Recently, pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified in familial Parkinsonism. Individuals in some of these families developed symptoms of dementia with Lewy-bodies and AD. The LRRK2 gene is also located within a locus on chromosome 12 reported in late-onset AD, and is therefore a good candidate gene for dementia. A series of 242 patients from Norway diagnosed clinically with dementia were included in the study, the majority were diagnosed with AD. Individuals were screened for the presence of seven known pathogenic mutations previously reported in the LRRK2 gene. We did not identify LRRK2 mutations in our series of dementia patients, indicating that known pathogenic mutations are not common in patients clinically diagnosed with AD. However, these results do not exclude a possible role of other genetic variants within the LRRK2 gene in AD or other forms of dementia.

Original languageEnglish (US)
Pages (from-to)1201-1205
Number of pages5
JournalMechanisms of Ageing and Development
Volume126
Issue number11
DOIs
StatePublished - Nov 1 2005

    Fingerprint

Keywords

  • Alzheimer's disease
  • Dementia
  • Genetics
  • LRRK2

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Cite this

Toft, M., Sando, S. B., Melquist, S., Ross, O. A., White, L. R., Aasly, J. O., & Farrer, M. J. (2005). LRRK2 mutations are not common in Alzheimer's disease. Mechanisms of Ageing and Development, 126(11), 1201-1205. https://doi.org/10.1016/j.mad.2005.06.010