LRRK2 and Parkinson's disease in Norway

M. Toft, K. Haugarvoll, Owen A Ross, M. J. Farrer, J. O. Aasly

Research output: Contribution to journalArticle

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Abstract

Objectives - Mutations in the LRRK2 gene have been associated with both familial and sporadic late-onset Parkinson's disease. A large number of mutations in this gene have been identified; however, for many of these variants, the pathogenicity and relative frequency are unknown. Herein, we investigate the frequency of a number of recently identified LRRK2 mutations in Norway. Methods - We genotyped eight putatively pathogenic LRRK2 mutations (R793M, R1067Q, I1371V, IVS31+3 A>G, M1869T, R1941H, T2356I and G2385R) in a series of 433 patients with Parkinson's disease and 587 controls from Norway. An intronic polymorphism previously reported to be associated with disease susceptibility was also examined (rs10506151). Results - The Lrrk2 R793M substitution was found in two healthy individuals. No other LRRK2 mutations were identified in the Norwegian population, and furthermore no association was observed between rs10506151 and Parkinson's disease (P = 0.41). Conclusions - LRRK2 mutations other than the Lrrk2 G2019S mutation are rare in Norway. Our results indicate that the Lrrk2 R793M substitution is most likely a rare polymorphism.

Original languageEnglish (US)
Pages (from-to)72-75
Number of pages4
JournalActa Neurologica Scandinavica
Volume115
Issue numberSUPPL.187
DOIs
StatePublished - May 2007

Fingerprint

Norway
Parkinson Disease
Mutation
Disease Susceptibility
Genes
Virulence
Population

Keywords

  • Genetics
  • LRRK2
  • Mutation
  • Norway
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Toft, M., Haugarvoll, K., Ross, O. A., Farrer, M. J., & Aasly, J. O. (2007). LRRK2 and Parkinson's disease in Norway. Acta Neurologica Scandinavica, 115(SUPPL.187), 72-75. https://doi.org/10.1111/j.1600-0404.2007.00852.x

LRRK2 and Parkinson's disease in Norway. / Toft, M.; Haugarvoll, K.; Ross, Owen A; Farrer, M. J.; Aasly, J. O.

In: Acta Neurologica Scandinavica, Vol. 115, No. SUPPL.187, 05.2007, p. 72-75.

Research output: Contribution to journalArticle

Toft, M, Haugarvoll, K, Ross, OA, Farrer, MJ & Aasly, JO 2007, 'LRRK2 and Parkinson's disease in Norway', Acta Neurologica Scandinavica, vol. 115, no. SUPPL.187, pp. 72-75. https://doi.org/10.1111/j.1600-0404.2007.00852.x
Toft, M. ; Haugarvoll, K. ; Ross, Owen A ; Farrer, M. J. ; Aasly, J. O. / LRRK2 and Parkinson's disease in Norway. In: Acta Neurologica Scandinavica. 2007 ; Vol. 115, No. SUPPL.187. pp. 72-75.
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