LRP5/6 in Wnt signaling and tumorigenesis

Yonghe Li, Guojun Bu

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

The canonical Wnt signaling pathway is frequently overactivated in several types of human cancer. Defects in different components of the Wnt signaling pathway promote tumorigenesis and tumor progression. Accordingly, the pathway has been intensely studied to understand its importance in cancer biology and as therapeutic target. Recent studies have found that the low-density lipoprotein receptor-related protein (LRP)5 and 6 are essential Wnt coreceptors and interact with several key components of the Wnt signaling pathway. Furthermore, it has been demonstrated that LRP5 and 6 are potential oncogenic proteins. Thus, blockade of LRP56 function may lead to new strategies in cancer treatment.

Original languageEnglish (US)
Pages (from-to)673-681
Number of pages9
JournalFuture Oncology
Volume1
Issue number5
DOIs
StatePublished - Oct 1 2005

Keywords

  • Dkk1
  • Wnt receptor
  • canonical Wnt signaling
  • low-density lipoprotein receptor-related protein 5 and 6
  • oncogene
  • tumor suppressor
  • tumorigenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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