LRP1B functions as a receptor for Pseudomonas exotoxin

Diana V. Pastrana, Alison J. Hanson, Jane Knisely, Guojun Bu, David J. FitzGerald

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors, among them Pseudomonas Exotoxin A (PE). Previously, low-density lipoprotein receptor-related protein 1 (LRP1) was shown to be the primary receptor for PE. In this report, we show that a close family member, LRP1B, can also function as a receptor.

Original languageEnglish (US)
Pages (from-to)234-239
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1741
Issue number3
DOIs
StatePublished - Sep 25 2005

Keywords

  • ADP-ribosylation
  • LRP1
  • LRP1B
  • Pseudomonas
  • Receptor
  • Toxin

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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