LRP and Alzheimer's disease

Celina V. Zerbinatti, Guojun D Bu

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The low-density lipoprotein receptor (LDLR)-related protein, LRP, is a unique member of the LDLR family. Frequently referred to as a scavenger receptor, LRP is a large transmembrane endocytic receptor that can bind and internalize many functionally distinct ligands. Besides its role as a cargo-receptor, LRP has also been implicated in many signaling pathways. LRP knockout mice die at early embryonic age, which strongly suggests that LRP's functions are essential for normal development. Within the CNS, LRP is highly expressed in neuronal cell bodies and dendritic processes. In vitro, neurite outgrowth is stimulated by apolipoprotein E (apoE)-containing lipoprotein particles via binding to LRP. ApoE is the major cholesterol transporter in the brain and human carriers of one or two copies of the ε4 allele of apoE are at a higher risk of developing Alzheimer's disease (AD). LRP also binds the amyloid precursor protein (APP) and its proteolytic fragment, the amyloid-β peptide (Aβ), which are major players in the pathogenesis of AD. Finally, LRP has been linked to AD by genetic evidence. In this review we discuss the potential mechanisms by which LRP can affect APP and Aβ metabolism, and therefore contribute to the pathogenesis of AD.

Original languageEnglish (US)
Pages (from-to)123-135
Number of pages13
JournalReviews in the Neurosciences
Volume16
Issue number2
StatePublished - 2005
Externally publishedYes

Fingerprint

Alzheimer Disease
Serum Amyloid A Protein
Amyloid beta-Protein Precursor
LDL Receptors
Apolipoproteins E
LDL-Receptor Related Proteins
Apolipoprotein E4
Scavenger Receptors
Amyloid
Knockout Mice
Lipoproteins
Alleles
Cholesterol
Ligands
Brain

Keywords

  • Alzheimer's disease
  • Amyloid-β peptide
  • ApoE
  • APP
  • Endocytosis
  • LRP

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Zerbinatti, C. V., & Bu, G. D. (2005). LRP and Alzheimer's disease. Reviews in the Neurosciences, 16(2), 123-135.

LRP and Alzheimer's disease. / Zerbinatti, Celina V.; Bu, Guojun D.

In: Reviews in the Neurosciences, Vol. 16, No. 2, 2005, p. 123-135.

Research output: Contribution to journalArticle

Zerbinatti, CV & Bu, GD 2005, 'LRP and Alzheimer's disease', Reviews in the Neurosciences, vol. 16, no. 2, pp. 123-135.
Zerbinatti, Celina V. ; Bu, Guojun D. / LRP and Alzheimer's disease. In: Reviews in the Neurosciences. 2005 ; Vol. 16, No. 2. pp. 123-135.
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