Lower Hounsfield Units and Severe Multifidus Sarcopenia Are Independent Predictors of Increased Risk for Proximal Junctional Kyphosis and Failure Following Thoracolumbar Fusion

Zachariah W. Pinter, Anthony L. Mikula, Sarah E. Townsley, Harold I. Salmons Iv, Nikita Lakomkin, Giorgos D. Michalopoulos, Ahmad Nassr, Brett A. Freedman, Mohamad Bydon, Jeremy Fogelson, Arjun S. Sebastian, Benjamin D. Elder

Research output: Contribution to journalArticlepeer-review

Abstract

Study Design. Retrospective cohort study. Objective. The purpose of the present study was to assess the impact of sarcopenia on the development of proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) following thoracolumbar spine fusion surgery using opportunistic evaluation of paraspinal fatty degeneration on preoperative magnetic resonance imaging. Summary of Background Data. While paraspinal sarcopenia has been shown to have detrimental consequences following posterior cervicothoracic fusions, the impact of paraspinal sarcopenia on PJK and PJF following thoracolumbar spine fusion surgery remains unknown. Materials and Methods. We performed a retrospective review of patients who underwent posterior spine fusion surgery that extended caudally to the pelvis and terminated cranially between T10 and L2 between 2010 and 2017. The cohort was divided into three groups: (1) patients without PJK or PJF, (2) patients with PJK but no PJF, and (3) patients with PJF. Univariate and multivariate analyses were performed to determine risk factors for the development of proximal junctional complications. Results. We identified 150 patients for inclusion in this study. Mean Hounsfield Units at the upper instrumented vertebra (UIV) was 148.3±34.5 in the cohort of patients without PJK or PJF, which was substantially higher than values recorded in the PJK (117.8±41.9) and PJF (118.8±41.8) subgroups (P<0.001). Severe multifidus sarcopenia was identified at a much higher rate in the subgroups of patients who developed PJK (76.0%) and PJF (78.9%) than in the subgroup of patients who developed neither PJK nor PJF (34.0%; P<0.001). Multivariate analysis demonstrated both low HU at the UIV and moderate-severe multifidus sarcopenia to be risk factors for the development of PJK and PJF. Conclusion. The results of this study suggest severe paraspinal sarcopenia and diminished bone density at the UIV impart an increased risk of developing PJK and PJF, while markers of systemic frailty such as modified Frailty Index and Charlson Comorbidity Index are not associated with an increased risk of these complications. Level of Evidence. III.

Original languageEnglish (US)
Pages (from-to)223-231
Number of pages9
JournalSpine
Volume48
Issue number4
DOIs
StatePublished - Feb 15 2023

Keywords

  • Goutalier
  • Hounsfield Units
  • PJF
  • PJK
  • bone mineral density
  • proximal junctional failure
  • proximal junctional kyphosis
  • sarcopenia

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

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