Lower body muscle mass and lower body negative pressure tolerance in men and women

L. A. Lawler, S. L. Mulvagh, J. R. Halliwill, Michael Joseph Joyner

Research output: Contribution to journalArticle

Abstract

To explore the hypothesis that lower body muscle mass might be associated with orthostatic intolerance, 18 healthy volunteers (18-48 yrs, 10 ♂, 8 ♀) underwent graded lower body negative pressure (LBNP) consisting of six, 5-minute stages of suction up to 60 mmHg in 10mmHg increments. Leg muscle mass was assessed by dual energy X-ray absorptiometry. All subjects received standard intravenous hydration for 12-16 hours prior to the study. Six men and 4 women completed each stage of LBNP. Four men and 4 women developed pre-syncopal symptoms, including marked bradycardia, at LBNP levels of 30 mmHg (n=2; 1 ♂, 1 ♀), 40 mmHg (n=2; 1 ♂, 1 female;), and 50 mmHg (n=4; 2 ♂, 2 female;). The pre-syncopal subjects had leg muscle masses ranging from 19.5 kg to 25.2 kg in men (SEM=1.04), and 11.7 kg to 16.6 kg in women (SEM=1.04). In subjects that completed all stages of LBNP, leg muscle mass ranged from 17.5 kg to 24.1 kg in men (SEM=1.04), and 10.4 kg to 18.0 kg in women (SEM =1.61). These data suggest that leg muscle mass is not a critical determinant of LBNP tolerance in otherwise healthy men and women.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

Fingerprint

Lower Body Negative Pressure
Muscle
Leg
legs
Muscles
muscles
Scanning electron microscopy
Orthostatic Intolerance
dual-energy X-ray absorptiometry
Photon Absorptiometry
Suction
Bradycardia
Hydration
signs and symptoms (animals and humans)
volunteers
Healthy Volunteers
X rays

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Lower body muscle mass and lower body negative pressure tolerance in men and women. / Lawler, L. A.; Mulvagh, S. L.; Halliwill, J. R.; Joyner, Michael Joseph.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Lawler, L. A. ; Mulvagh, S. L. ; Halliwill, J. R. ; Joyner, Michael Joseph. / Lower body muscle mass and lower body negative pressure tolerance in men and women. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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