Low R-wave amplitude in the right precordial leads in children with symptomatic doxorubicin cardiomyopathy

Masakazu Umemoto; Eiichi Azuma; Masahiro Itoh; Yoshihiro Komada; Masaru Ido; Hajime Kawasaki; Hirohito Kita; Minoru Sakurai

doi:10.1007/BF00796989

Low R-wave amplitude in the right precordial leads in children with symptomatic doxorubicin cardiomyopathy

Masakazu Umemoto, Eiichi Azuma, Masahiro Itoh, Yoshihiro Komada, Masaru Ido, Hajime Kawasaki, Hirohito Kita, Minoru Sakurai

Allergy, Asthma and Clinical Immunology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Electrocardiographic (ECG) findings were studied in four patients with doxorubicin cardiomyopathy. In all patients with congestive heart failure (CHF), the ECGs had a low R-wave and low R/S ratio in lead V₁. Our study suggests that increased injury to myocardial cells in the regions of the anterior septum and anterior left ventricular wall may be important in the pathogenesis of doxorubicin cardiomyopathy. Eight years later, cardiac recovery from CHF occurred with a normal ECG and left ventricular ejection fraction in one patient, indicating that CHF may be reversible in certain cases.

Original language	English (US)
Pages (from-to)	107-109
Number of pages	3
Journal	Pediatric Cardiology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1007/BF00796989
State	Published - Mar 1993

Keywords

Cardiomyopathy
Doxorubicin
Electrocardiogram

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

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10.1007/BF00796989

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title = "Low R-wave amplitude in the right precordial leads in children with symptomatic doxorubicin cardiomyopathy",

abstract = "Electrocardiographic (ECG) findings were studied in four patients with doxorubicin cardiomyopathy. In all patients with congestive heart failure (CHF), the ECGs had a low R-wave and low R/S ratio in lead V1. Our study suggests that increased injury to myocardial cells in the regions of the anterior septum and anterior left ventricular wall may be important in the pathogenesis of doxorubicin cardiomyopathy. Eight years later, cardiac recovery from CHF occurred with a normal ECG and left ventricular ejection fraction in one patient, indicating that CHF may be reversible in certain cases.",

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author = "Masakazu Umemoto and Eiichi Azuma and Masahiro Itoh and Yoshihiro Komada and Masaru Ido and Hajime Kawasaki and Hirohito Kita and Minoru Sakurai",

year = "1993",

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doi = "10.1007/BF00796989",

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T1 - Low R-wave amplitude in the right precordial leads in children with symptomatic doxorubicin cardiomyopathy

AU - Umemoto, Masakazu

AU - Azuma, Eiichi

AU - Itoh, Masahiro

AU - Komada, Yoshihiro

AU - Ido, Masaru

AU - Kawasaki, Hajime

AU - Kita, Hirohito

AU - Sakurai, Minoru

PY - 1993/3

Y1 - 1993/3

N2 - Electrocardiographic (ECG) findings were studied in four patients with doxorubicin cardiomyopathy. In all patients with congestive heart failure (CHF), the ECGs had a low R-wave and low R/S ratio in lead V1. Our study suggests that increased injury to myocardial cells in the regions of the anterior septum and anterior left ventricular wall may be important in the pathogenesis of doxorubicin cardiomyopathy. Eight years later, cardiac recovery from CHF occurred with a normal ECG and left ventricular ejection fraction in one patient, indicating that CHF may be reversible in certain cases.

AB - Electrocardiographic (ECG) findings were studied in four patients with doxorubicin cardiomyopathy. In all patients with congestive heart failure (CHF), the ECGs had a low R-wave and low R/S ratio in lead V1. Our study suggests that increased injury to myocardial cells in the regions of the anterior septum and anterior left ventricular wall may be important in the pathogenesis of doxorubicin cardiomyopathy. Eight years later, cardiac recovery from CHF occurred with a normal ECG and left ventricular ejection fraction in one patient, indicating that CHF may be reversible in certain cases.

KW - Cardiomyopathy

KW - Doxorubicin

KW - Electrocardiogram

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Low R-wave amplitude in the right precordial leads in children with symptomatic doxorubicin cardiomyopathy

Abstract

Keywords

ASJC Scopus subject areas

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