Low neural exosomal levels of cellular survival factors in Alzheimer's disease

Edward J. Goetzl, Adam Boxer, Janice B. Schwartz, Erin L. Abner, Ronald Carl Petersen, Bruce L. Miller, Olga D. Carlson, Maja Mustapic, Dimitrios Kapogiannis

Research output: Contribution to journalArticle

67 Scopus citations


Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2–10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.

Original languageEnglish (US)
Pages (from-to)769-773
Number of pages5
JournalAnnals of Clinical and Translational Neurology
Issue number7
StatePublished - Jul 1 2015


ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Goetzl, E. J., Boxer, A., Schwartz, J. B., Abner, E. L., Petersen, R. C., Miller, B. L., Carlson, O. D., Mustapic, M., & Kapogiannis, D. (2015). Low neural exosomal levels of cellular survival factors in Alzheimer's disease. Annals of Clinical and Translational Neurology, 2(7), 769-773. https://doi.org/10.1002/acn3.211