Low neural exosomal levels of cellular survival factors in Alzheimer's disease

Edward J. Goetzl, Adam Boxer, Janice B. Schwartz, Erin L. Abner, Ronald Carl Petersen, Bruce L. Miller, Olga D. Carlson, Maja Mustapic, Dimitrios Kapogiannis

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2–10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.

Original languageEnglish (US)
Pages (from-to)769-773
Number of pages5
JournalAnnals of Clinical and Translational Neurology
Volume2
Issue number7
DOIs
StatePublished - Jul 1 2015

Fingerprint

Alzheimer Disease
Transcription Factors
Transcriptional Silencer Elements
Survival
Frontotemporal Dementia
Low Density Lipoprotein Receptor-Related Protein-6
Exosomes
Shock
Proteins
Hot Temperature

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Goetzl, E. J., Boxer, A., Schwartz, J. B., Abner, E. L., Petersen, R. C., Miller, B. L., ... Kapogiannis, D. (2015). Low neural exosomal levels of cellular survival factors in Alzheimer's disease. Annals of Clinical and Translational Neurology, 2(7), 769-773. https://doi.org/10.1002/acn3.211

Low neural exosomal levels of cellular survival factors in Alzheimer's disease. / Goetzl, Edward J.; Boxer, Adam; Schwartz, Janice B.; Abner, Erin L.; Petersen, Ronald Carl; Miller, Bruce L.; Carlson, Olga D.; Mustapic, Maja; Kapogiannis, Dimitrios.

In: Annals of Clinical and Translational Neurology, Vol. 2, No. 7, 01.07.2015, p. 769-773.

Research output: Contribution to journalArticle

Goetzl, EJ, Boxer, A, Schwartz, JB, Abner, EL, Petersen, RC, Miller, BL, Carlson, OD, Mustapic, M & Kapogiannis, D 2015, 'Low neural exosomal levels of cellular survival factors in Alzheimer's disease', Annals of Clinical and Translational Neurology, vol. 2, no. 7, pp. 769-773. https://doi.org/10.1002/acn3.211
Goetzl, Edward J. ; Boxer, Adam ; Schwartz, Janice B. ; Abner, Erin L. ; Petersen, Ronald Carl ; Miller, Bruce L. ; Carlson, Olga D. ; Mustapic, Maja ; Kapogiannis, Dimitrios. / Low neural exosomal levels of cellular survival factors in Alzheimer's disease. In: Annals of Clinical and Translational Neurology. 2015 ; Vol. 2, No. 7. pp. 769-773.
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