TY - JOUR
T1 - Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms
AU - Keyzner, Alla
AU - D'Souza, Anita
AU - Lacy, Martha
AU - Gertz, Morie
AU - Hayman, Suzanne
AU - Buadi, Francis
AU - Kumar, Shaji
AU - Dingli, David
AU - Engebretson, Ann
AU - Tong, Caili
AU - Dispenzieri, Angela
N1 - Funding Information:
This work was supported in part by the Jabbs Foundation , the Henry J. Predolin Foundation , the Andrew and Lillian A Posey Foundation , and the Robert A. Kyle Hematologic Malignancies Fund .
PY - 2013/9
Y1 - 2013/9
N2 - A rare, multisystem, plasma cell neoplasm, POEMS (polyradiculoneuropathy, organomegaly, endocrinopathy, M-spike, skin changes) syndrome is characterized by an abundance of proinflammatory and angiogenic cytokines. Patients with POEMS are known to have a high incidence of engraftment syndrome after autologous stem cell transplantation. We conducted a pilot study assessing levels of 30 different pro- and anti-inflammatory cytokines before and serially after transplantation in 18 patients with plasma cell neoplasms: POEMS syndrome (n=9), multiple myeloma (n=4), and amyloidosis (n=5). We show that POEMS patients have higher pretransplantation levels of IL-4, IL-10, IL-13, IFN-α, and EGF as compared with those with non-POEMS plasma cell neoplasms. Higher pre- and posttransplantation IL-13 levels correlated with delayed neutrophil engraftment in POEMS patients. Low posttransplantation IL-1RA levels correlated with engraftment syndrome in both POEMS and non-POEMS patients. We conclude that differences in the peri-transplantation cytokine milieu may explain the higher transplantation morbidity in patients with POEMS syndrome. Our results need validation in a larger cohort.
AB - A rare, multisystem, plasma cell neoplasm, POEMS (polyradiculoneuropathy, organomegaly, endocrinopathy, M-spike, skin changes) syndrome is characterized by an abundance of proinflammatory and angiogenic cytokines. Patients with POEMS are known to have a high incidence of engraftment syndrome after autologous stem cell transplantation. We conducted a pilot study assessing levels of 30 different pro- and anti-inflammatory cytokines before and serially after transplantation in 18 patients with plasma cell neoplasms: POEMS syndrome (n=9), multiple myeloma (n=4), and amyloidosis (n=5). We show that POEMS patients have higher pretransplantation levels of IL-4, IL-10, IL-13, IFN-α, and EGF as compared with those with non-POEMS plasma cell neoplasms. Higher pre- and posttransplantation IL-13 levels correlated with delayed neutrophil engraftment in POEMS patients. Low posttransplantation IL-1RA levels correlated with engraftment syndrome in both POEMS and non-POEMS patients. We conclude that differences in the peri-transplantation cytokine milieu may explain the higher transplantation morbidity in patients with POEMS syndrome. Our results need validation in a larger cohort.
KW - Cytokines
KW - IL-13
KW - IL-1RA
KW - Neutrophil engraftment
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U2 - 10.1016/j.bbmt.2013.06.012
DO - 10.1016/j.bbmt.2013.06.012
M3 - Article
C2 - 23792270
AN - SCOPUS:84882765745
SN - 1083-8791
VL - 19
SP - 1395
EP - 1398
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 9
ER -