Abstract
Pulmonary hypertension (PH) can complicate myelofibrosis with myeloid metaplasia (MMM), may arise in the absence of evidence for thromboembolic disease and carries a grim prognosis. Four patients with MMM and severe symptomatic PH were treated with whole-lung external beam radiotherapy in a single fraction of 100 cGy. Within 72 h, each patient noted marked symptomatic improvement and had relief of hypoxia and reduction of oedema and/or ascites. Three of the four patients enjoyed an objective improvement in pulmonary artery systolic pressure as measured by transthoracic Doppler echocardiography. Low-dose lung radiotherapy may be a useful palliative tool for patients with MMM complicated by PH.
Original language | English (US) |
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Pages (from-to) | 813-816 |
Number of pages | 4 |
Journal | British journal of haematology |
Volume | 118 |
Issue number | 3 |
DOIs | |
State | Published - 2002 |
Keywords
- Extramedullary haematopoiesis
- Myelofibrosis
- Pulmonary hypertension
- Radiotherapy
ASJC Scopus subject areas
- Hematology