Low-dose, single-fraction, whole-lung radiotherapy for pulmonary hypertension associated with myelofibrosis with myeloid metaplasia

David P. Steensma, C. Christopher Hook, Scott L. Stafford, Ayalew Tefferi

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Pulmonary hypertension (PH) can complicate myelofibrosis with myeloid metaplasia (MMM), may arise in the absence of evidence for thromboembolic disease and carries a grim prognosis. Four patients with MMM and severe symptomatic PH were treated with whole-lung external beam radiotherapy in a single fraction of 100 cGy. Within 72 h, each patient noted marked symptomatic improvement and had relief of hypoxia and reduction of oedema and/or ascites. Three of the four patients enjoyed an objective improvement in pulmonary artery systolic pressure as measured by transthoracic Doppler echocardiography. Low-dose lung radiotherapy may be a useful palliative tool for patients with MMM complicated by PH.

Original languageEnglish (US)
Pages (from-to)813-816
Number of pages4
JournalBritish journal of haematology
Volume118
Issue number3
DOIs
StatePublished - 2002

Keywords

  • Extramedullary haematopoiesis
  • Myelofibrosis
  • Pulmonary hypertension
  • Radiotherapy

ASJC Scopus subject areas

  • Hematology

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