Low-dose simvastatin for the treatment of hypercholesterolaemia in recipients of cardiac transplantation

M. Barbir, M. Rose, S. Kushwaha, S. Akl, A. Mitchell, M. Yacoub

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

There is increasing evidence that hypercholesterolaemia is an important contributor to the development of accelerated coronary arterial disease in the cardiac allograft. The optimal drug therapy of hypercholesterolaemia in recipients after cardiac transplantation, however, has not been defined. Simvastatin (an inhibitor of hydroxy-methyl glutaryl-coenzyme A reductase), at a dose of 10 mg/day, was administered to 12 recipients with serum total cholesterol ≥ 7.8 mmol/l and serum triglyceride ≤ 4.5 mmol/l refractory to dietary measures during a follow-up period of 1-5 yearsafter cardiac transplantation. All patients received maintenance doses of cyclosporin A and, in some instances, azathioprine and prednisolone. After 2 months treatment with simvastatin, serum total cholesterol was significantly reduced from 8.8 ± 0.3 mmol/l (mean ± SEM) to 5.5 ± 0.5 mmol/l, P < 0.001, low density cholesterol from 6.6 ± 0.4 to 3.8 ± 0.3 mmol/l, P < 0.001 and triglycerides from 2.4 ± 0.2 mmol/l to 1.8 ± 0.2 mmol/l, P < 0.005. These changes were maintained after a period of treatment of 8 months. Serum high density cholesterol, hepatic transaminase levels, serum creatinine, creatine kinase and cyclosporin A blood levels were not altered by treatment with simvastatin. It is concluded that, in this study group, low-dose simvastatin appears to be well tolerated and has favourable lipid modifying properties.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalInternational Journal of Cardiology
Volume33
Issue number2
DOIs
StatePublished - Nov 1991

Keywords

  • Cardiac transplantation
  • Cyclosporin
  • Hypercholesterolemia
  • Simvastatin
  • Triglyceride

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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