Low dose rate prostate brachytherapy

Bradley J. Stish, Brian J. Davis, Lance A. Mynderse, Robert H. McLaren, Christopher L. Deufel, Richard Choo

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Low dose rate (LDR) prostate brachytherapy is an evidence based radiation technique with excellent oncologic outcomes. By utilizing direct image guidance for radioactive source placement, LDR brachytherapy provides superior radiation dose escalation and conformality compared to external beam radiation therapy (EBRT). With this level of precision, late grade 3 or 4 genitourinary or gastrointestinal toxicity rates are typically between 1% and 4%. Furthermore, when performed as a same day surgical procedure, this technique provides a cost effective and convenient strategy. A large body of literature with robust follow-up has led multiple expert consensus groups to endorse the use of LDR brachytherapy as an appropriate management option for all risk groups of non-metastatic prostate cancer. LDR brachytherapy is often effective when delivered as a monotherapy, although for some patients with intermediate or high-risk disease, optimal outcome are achieved in combination with supplemental EBRT and/or androgen deprivation therapy (ADT). In addition to reviewing technical aspects and reported clinical outcomes of LDR prostate brachytherapy, this article will focus on the considerations related to appropriate patient selection and other aspects of its use in the treatment of prostate cancer.

Original languageEnglish (US)
Pages (from-to)341-356
Number of pages16
JournalTranslational Andrology and Urology
Volume7
Issue number3
DOIs
StatePublished - Jun 1 2018

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Keywords

  • Low dose rate brachytherapy
  • Prostate cancer
  • Radiation therapy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

Cite this

Stish, B. J., Davis, B. J., Mynderse, L. A., McLaren, R. H., Deufel, C. L., & Choo, R. (2018). Low dose rate prostate brachytherapy. Translational Andrology and Urology, 7(3), 341-356. https://doi.org/10.21037/tau.2017.12.15