Low-dose enteric-coated aspirin: A practical approach to continuous-release low-dose aspirin and presystemic acetylation of human platelet cyclooxygenase

Joseph A. Jakubowski, Meir J. Stampfer, Raymond Vaillancourt, Douglas Orrick Faigel, Daniel Deykin

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Abstract

Using a granular enteric-coated aspirin (ECA) preparation, we achieved continuous release of low-dose aspirin and associated inhibition of platelet reactivity. The lowest once-daily dose that produced >90% inhibition of serum thromboxane (TX) A2 after 7 days was 80 mg. The time course of inhibition after the first dose indicated a gradual release of aspirin over a period of 8 hours. We subsequently fractionated this 80 mg dose into three times daily doses of 27 mg that were administered to nine healthy men for 7 days. This regimen resulted in 96% inhibition of serum TXA2 generation (P < 0.001), inhibition of in vitro platelet aggregation (P < 0.05), prolongation of the bleeding time by 75% (P < 0.01), and a threefold increase in inhibition of platelet aggregation by prostacyclin (P < 0.01) compared with pre-ECA values. In contrast to our previous study using daily 80 mg doses of ECA, after the 27 mg three times daily regimen we found a significant increase in circulating platelet cyclooxygenase activity 24 hours after the final dose (P < 0.05). This Immediate recovery indicates active megakaryocyte cyclooxygenase and suggests that acetylation of platelet cyclooxygenase was restricted to the presystemic circulation. We conclude that longterm dosing with 27 mg ECA three times daily results in profound inhibition of platelet TXA2 production, and diminished in vitro and in vivo platelet reactivity. This regimen provides a practical approach to achieving continuous release of low-dose aspirin and possible presystemic acetylation of platelet cyclooxygenase.

Original languageEnglish (US)
Pages (from-to)616-621
Number of pages6
JournalThe Journal of Laboratory and Clinical Medicine
Volume108
Issue number6
StatePublished - 1986
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

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