Low-density lipoprotein receptor family: Endocytosis and signal transduction

Y. Li, J. Cam, Guojun D Bu

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

The low-density lipoprotein receptor (LDLR) family is composed of a class of single transmembrane glycoproteins, generally recognized as cell surface endocytic receptors, which bind and internalize extracellular ligands for degradation by lysosomes. Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. Recently, information regarding the structural and functional elements within their cytoplasmic tails has begun to emerge, which suggests that members of the LDLR family function not only in receptor-mediated endocytosis, but also in transducing signals that are important during embryonic development and the pathogenesis of Alzheimer's disease. This review focuses on recent knowledge of the structural and functional aspects of LDLR family members in endocytosis and signal transduction. The relationship of these functions to the development of the neuronal system and in the pathogenesis of Alzheimer's disease is specifically discussed.

Original languageEnglish (US)
Pages (from-to)53-67
Number of pages15
JournalMolecular Neurobiology
Volume23
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

LDL Receptors
Endocytosis
Signal Transduction
Alzheimer Disease
Ligands
Cell Surface Receptors
Lysosomes
Embryonic Development
Glycoproteins

Keywords

  • Alzheimer's disease
  • ApoER2
  • Endocytosis
  • LDL receptor family
  • LRP
  • LRP6
  • Signaling
  • VLDL receptor

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Low-density lipoprotein receptor family : Endocytosis and signal transduction. / Li, Y.; Cam, J.; Bu, Guojun D.

In: Molecular Neurobiology, Vol. 23, No. 1, 2001, p. 53-67.

Research output: Contribution to journalArticle

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