Low-density lipoprotein receptor family: Endocytosis and signal transduction

Y. Li, J. Cam, G. Bu

Research output: Contribution to journalReview article

98 Scopus citations

Abstract

The low-density lipoprotein receptor (LDLR) family is composed of a class of single transmembrane glycoproteins, generally recognized as cell surface endocytic receptors, which bind and internalize extracellular ligands for degradation by lysosomes. Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. Recently, information regarding the structural and functional elements within their cytoplasmic tails has begun to emerge, which suggests that members of the LDLR family function not only in receptor-mediated endocytosis, but also in transducing signals that are important during embryonic development and the pathogenesis of Alzheimer's disease. This review focuses on recent knowledge of the structural and functional aspects of LDLR family members in endocytosis and signal transduction. The relationship of these functions to the development of the neuronal system and in the pathogenesis of Alzheimer's disease is specifically discussed.

Original languageEnglish (US)
Pages (from-to)53-67
Number of pages15
JournalMolecular Neurobiology
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2001

Keywords

  • Alzheimer's disease
  • ApoER2
  • Endocytosis
  • LDL receptor family
  • LRP
  • LRP6
  • Signaling
  • VLDL receptor

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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