Low-density lipoprotein particle size and coronary atherosclerosis in subjects belonging to hypertensive sibships

Iftikhar Jan Kullo, Kent R Bailey, Joseph P. McConnell, Patricia A. Peyser, Lawrence F. Bielak, Sharon L R Kardia, Patrick F. Sheedy, Eric Boerwinkle, Stephen T Turner

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Dyslipidemia in hypertensive sibships may be characterized by atherogenic small low-density lipoprotein (LDL) particles. Whether LDL particle size is associated with the extent of coronary atherosclerosis in hypertensive sibships is unknown. Subjects (n = 792, mean age 62 years, 60% women) were ascertained through sibships containing at least two individuals with essential hypertension diagnosed before age 60 years. The LDL particle size was measured by polyacrylamide gel electrophoresis. Coronary artery calcium (CAC) was measured noninvasively by electron beam computed tomography, and CAC score was calculated using the method of Agatston et al. Sex-specific multiple regression models were used to assess independent predictors of LDL particle size and the association of LDL particle size with CAC. In all, 76% of women and 77% of men were hypertensive. In each sex, independent predictors of smaller LDL particle size were total cholesterol, triglycerides, and lower HDL cholesterol. In women, greater age was an additional predictor of smaller LDL particle size. After adjustment for age and statin use, LDL particle size was significantly associated with the amount of CAC in women but not in men. After further adjustment for HDL cholesterol, triglycerides, diabetes, smoking, and hypertension, LDL particle size was not independently associated with CAC in either sex. After adjustment for age and statin use, LDL particle size was found to be significantly related to CAC quantity in women but not in men belonging to hypertensive sibships. In women, LDL particle size may mediate some of the atherogenic effects of low-HDL cholesterol-high-triglyceride dyslipidemia, but does not appear to be independently associated with the extent of coronary atherosclerosis in either sex.

Original languageEnglish (US)
Pages (from-to)845-851
Number of pages7
JournalAmerican Journal of Hypertension
Volume17
Issue number9
DOIs
StatePublished - Sep 2004

Fingerprint

LDL Lipoproteins
Particle Size
Coronary Artery Disease
Coronary Vessels
Calcium
HDL Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Triglycerides
Dyslipidemias
X Ray Computed Tomography
Polyacrylamide Gel Electrophoresis
Smoking
Cholesterol
Hypertension

Keywords

  • Atherosclerosis
  • coronary artery calcification
  • electron beam computed tomography
  • low-density lipoprotein particle size
  • risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Low-density lipoprotein particle size and coronary atherosclerosis in subjects belonging to hypertensive sibships. / Kullo, Iftikhar Jan; Bailey, Kent R; McConnell, Joseph P.; Peyser, Patricia A.; Bielak, Lawrence F.; Kardia, Sharon L R; Sheedy, Patrick F.; Boerwinkle, Eric; Turner, Stephen T.

In: American Journal of Hypertension, Vol. 17, No. 9, 09.2004, p. 845-851.

Research output: Contribution to journalArticle

Kullo, Iftikhar Jan ; Bailey, Kent R ; McConnell, Joseph P. ; Peyser, Patricia A. ; Bielak, Lawrence F. ; Kardia, Sharon L R ; Sheedy, Patrick F. ; Boerwinkle, Eric ; Turner, Stephen T. / Low-density lipoprotein particle size and coronary atherosclerosis in subjects belonging to hypertensive sibships. In: American Journal of Hypertension. 2004 ; Vol. 17, No. 9. pp. 845-851.
@article{3890163eab3c49c9b68e570e33b46e29,
title = "Low-density lipoprotein particle size and coronary atherosclerosis in subjects belonging to hypertensive sibships",
abstract = "Dyslipidemia in hypertensive sibships may be characterized by atherogenic small low-density lipoprotein (LDL) particles. Whether LDL particle size is associated with the extent of coronary atherosclerosis in hypertensive sibships is unknown. Subjects (n = 792, mean age 62 years, 60{\%} women) were ascertained through sibships containing at least two individuals with essential hypertension diagnosed before age 60 years. The LDL particle size was measured by polyacrylamide gel electrophoresis. Coronary artery calcium (CAC) was measured noninvasively by electron beam computed tomography, and CAC score was calculated using the method of Agatston et al. Sex-specific multiple regression models were used to assess independent predictors of LDL particle size and the association of LDL particle size with CAC. In all, 76{\%} of women and 77{\%} of men were hypertensive. In each sex, independent predictors of smaller LDL particle size were total cholesterol, triglycerides, and lower HDL cholesterol. In women, greater age was an additional predictor of smaller LDL particle size. After adjustment for age and statin use, LDL particle size was significantly associated with the amount of CAC in women but not in men. After further adjustment for HDL cholesterol, triglycerides, diabetes, smoking, and hypertension, LDL particle size was not independently associated with CAC in either sex. After adjustment for age and statin use, LDL particle size was found to be significantly related to CAC quantity in women but not in men belonging to hypertensive sibships. In women, LDL particle size may mediate some of the atherogenic effects of low-HDL cholesterol-high-triglyceride dyslipidemia, but does not appear to be independently associated with the extent of coronary atherosclerosis in either sex.",
keywords = "Atherosclerosis, coronary artery calcification, electron beam computed tomography, low-density lipoprotein particle size, risk factors",
author = "Kullo, {Iftikhar Jan} and Bailey, {Kent R} and McConnell, {Joseph P.} and Peyser, {Patricia A.} and Bielak, {Lawrence F.} and Kardia, {Sharon L R} and Sheedy, {Patrick F.} and Eric Boerwinkle and Turner, {Stephen T}",
year = "2004",
month = "9",
doi = "10.1016/j.amjhyper.2004.06.012",
language = "English (US)",
volume = "17",
pages = "845--851",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Low-density lipoprotein particle size and coronary atherosclerosis in subjects belonging to hypertensive sibships

AU - Kullo, Iftikhar Jan

AU - Bailey, Kent R

AU - McConnell, Joseph P.

AU - Peyser, Patricia A.

AU - Bielak, Lawrence F.

AU - Kardia, Sharon L R

AU - Sheedy, Patrick F.

AU - Boerwinkle, Eric

AU - Turner, Stephen T

PY - 2004/9

Y1 - 2004/9

N2 - Dyslipidemia in hypertensive sibships may be characterized by atherogenic small low-density lipoprotein (LDL) particles. Whether LDL particle size is associated with the extent of coronary atherosclerosis in hypertensive sibships is unknown. Subjects (n = 792, mean age 62 years, 60% women) were ascertained through sibships containing at least two individuals with essential hypertension diagnosed before age 60 years. The LDL particle size was measured by polyacrylamide gel electrophoresis. Coronary artery calcium (CAC) was measured noninvasively by electron beam computed tomography, and CAC score was calculated using the method of Agatston et al. Sex-specific multiple regression models were used to assess independent predictors of LDL particle size and the association of LDL particle size with CAC. In all, 76% of women and 77% of men were hypertensive. In each sex, independent predictors of smaller LDL particle size were total cholesterol, triglycerides, and lower HDL cholesterol. In women, greater age was an additional predictor of smaller LDL particle size. After adjustment for age and statin use, LDL particle size was significantly associated with the amount of CAC in women but not in men. After further adjustment for HDL cholesterol, triglycerides, diabetes, smoking, and hypertension, LDL particle size was not independently associated with CAC in either sex. After adjustment for age and statin use, LDL particle size was found to be significantly related to CAC quantity in women but not in men belonging to hypertensive sibships. In women, LDL particle size may mediate some of the atherogenic effects of low-HDL cholesterol-high-triglyceride dyslipidemia, but does not appear to be independently associated with the extent of coronary atherosclerosis in either sex.

AB - Dyslipidemia in hypertensive sibships may be characterized by atherogenic small low-density lipoprotein (LDL) particles. Whether LDL particle size is associated with the extent of coronary atherosclerosis in hypertensive sibships is unknown. Subjects (n = 792, mean age 62 years, 60% women) were ascertained through sibships containing at least two individuals with essential hypertension diagnosed before age 60 years. The LDL particle size was measured by polyacrylamide gel electrophoresis. Coronary artery calcium (CAC) was measured noninvasively by electron beam computed tomography, and CAC score was calculated using the method of Agatston et al. Sex-specific multiple regression models were used to assess independent predictors of LDL particle size and the association of LDL particle size with CAC. In all, 76% of women and 77% of men were hypertensive. In each sex, independent predictors of smaller LDL particle size were total cholesterol, triglycerides, and lower HDL cholesterol. In women, greater age was an additional predictor of smaller LDL particle size. After adjustment for age and statin use, LDL particle size was significantly associated with the amount of CAC in women but not in men. After further adjustment for HDL cholesterol, triglycerides, diabetes, smoking, and hypertension, LDL particle size was not independently associated with CAC in either sex. After adjustment for age and statin use, LDL particle size was found to be significantly related to CAC quantity in women but not in men belonging to hypertensive sibships. In women, LDL particle size may mediate some of the atherogenic effects of low-HDL cholesterol-high-triglyceride dyslipidemia, but does not appear to be independently associated with the extent of coronary atherosclerosis in either sex.

KW - Atherosclerosis

KW - coronary artery calcification

KW - electron beam computed tomography

KW - low-density lipoprotein particle size

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=4444248092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444248092&partnerID=8YFLogxK

U2 - 10.1016/j.amjhyper.2004.06.012

DO - 10.1016/j.amjhyper.2004.06.012

M3 - Article

C2 - 15363830

AN - SCOPUS:4444248092

VL - 17

SP - 845

EP - 851

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 9

ER -