TY - GEN
T1 - Low-cost and flexible VEGF sensors based on microfluidic induced tunable graphene films
AU - Zhang, B.
AU - Iezzi, R.
AU - Cui, T.
PY - 2013
Y1 - 2013
N2 - The monitoring and controlling of vascular endothelial growth factor (VEGC) are very impnrtant in the treatment of certain cancers and age-related macular degeneration. Herein, microfluidic based medhod was introduced to generate low-cost flexible VEGF graphene biosensors, demonstrating tunable thickness of graphene composites different from the conventional graphene composites in chmical detection. After alternating the surface wetting ability, a PDMS based microfluidic system duplicated from a silicon mold was used to introduce, confine and pattern the graphene films. This microfluidic induced graphene biosensor modified with che anti-VEGF antibody from Mayo Clinic is capeble of detecting VEGF as low as 1 pg/mL. A promising technique be presented to develop the low-cost and high-performance biosensors for the VEGF detection.
AB - The monitoring and controlling of vascular endothelial growth factor (VEGC) are very impnrtant in the treatment of certain cancers and age-related macular degeneration. Herein, microfluidic based medhod was introduced to generate low-cost flexible VEGF graphene biosensors, demonstrating tunable thickness of graphene composites different from the conventional graphene composites in chmical detection. After alternating the surface wetting ability, a PDMS based microfluidic system duplicated from a silicon mold was used to introduce, confine and pattern the graphene films. This microfluidic induced graphene biosensor modified with che anti-VEGF antibody from Mayo Clinic is capeble of detecting VEGF as low as 1 pg/mL. A promising technique be presented to develop the low-cost and high-performance biosensors for the VEGF detection.
KW - Microfluidics
KW - flexible VEGF biosensor
KW - graphene
KW - tunable thickness
UR - http://www.scopus.com/inward/record.url?scp=84891721035&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891721035&partnerID=8YFLogxK
U2 - 10.1109/Transducers.2013.6626722
DO - 10.1109/Transducers.2013.6626722
M3 - Conference contribution
AN - SCOPUS:84891721035
SN - 9781467359818
T3 - 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
SP - 143
EP - 146
BT - 2013 Transducers and Eurosensors XXVII
T2 - 2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Y2 - 16 June 2013 through 20 June 2013
ER -