TY - JOUR
T1 - Low accuracy of color Doppler ultrasound in the detection of proximal leg vein thrombosis in asymptomatic high-risk patients
AU - Davidson, Bruce L.
AU - Elliott, C. Gregory
AU - Lensing, Anthonie W.A.
PY - 1992/11/1
Y1 - 1992/11/1
N2 - Objective: To evaluate the ability of color Doppler ultrasound to detect proximal deep venous thrombosis (DVT) in asymptomatic high-risk patients who subsequently underwent contrast venography. Design: Prospective cohort study using blinded observers, with contrast venography as the comparison standard. Setting: Seven medical centers (university and community hospitals) participating in a clinical trial of low-molecular-weight heparin for prevention of DVT. Patients: A total of 385 consecutive patients undergoing elective unilateral hip or knee replacement. Measurements: Ten days after surgery or before hospital discharge (whichever occurred first), patients had bilateral color Doppler ultrasound examinations of the proximal veins of the lower extremities. Subsequently, a contrast venogram of the operated leg was obtained. Results: Color Doppler ultrasound studies and venograms were both evaluable in 319 of the 385 patients. Deep venous thrombosis was identified by contrast venography in 80 patients (prevalence, 25%; 95% Cl, 20% to 30%) and involved the proximal veins in 21 patients (prevalence, 7%; Cl, 4% to 10%). For proximal DvT, color Doppler ultrasound showed poor sensitivity (38%; Cl, 18% to 62%), moderately good specificity (92%; Cl, 89% to 95%), and a poor positive predictive value for this population (26%). Conclusion: Color Doppler ultrasound examinations are insensitive to proximal DVT in asymptomatic high-risk patients and should not be substituted for venography for identifying proximal DVT in such patients.
AB - Objective: To evaluate the ability of color Doppler ultrasound to detect proximal deep venous thrombosis (DVT) in asymptomatic high-risk patients who subsequently underwent contrast venography. Design: Prospective cohort study using blinded observers, with contrast venography as the comparison standard. Setting: Seven medical centers (university and community hospitals) participating in a clinical trial of low-molecular-weight heparin for prevention of DVT. Patients: A total of 385 consecutive patients undergoing elective unilateral hip or knee replacement. Measurements: Ten days after surgery or before hospital discharge (whichever occurred first), patients had bilateral color Doppler ultrasound examinations of the proximal veins of the lower extremities. Subsequently, a contrast venogram of the operated leg was obtained. Results: Color Doppler ultrasound studies and venograms were both evaluable in 319 of the 385 patients. Deep venous thrombosis was identified by contrast venography in 80 patients (prevalence, 25%; 95% Cl, 20% to 30%) and involved the proximal veins in 21 patients (prevalence, 7%; Cl, 4% to 10%). For proximal DvT, color Doppler ultrasound showed poor sensitivity (38%; Cl, 18% to 62%), moderately good specificity (92%; Cl, 89% to 95%), and a poor positive predictive value for this population (26%). Conclusion: Color Doppler ultrasound examinations are insensitive to proximal DVT in asymptomatic high-risk patients and should not be substituted for venography for identifying proximal DVT in such patients.
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M3 - Article
C2 - 1416575
AN - SCOPUS:0026787126
SN - 0003-4819
VL - 117
SP - 735
EP - 738
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 9
ER -