Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Jiyun Lee, Jianzhou Wang, Michael Torbenson, You Lu, Qiong Z. Liu, Shibo Li

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume196
Issue number2
DOIs
StatePublished - Jan 15 2010

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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