Abstract
We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.
Original language | English (US) |
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Pages (from-to) | 179-183 |
Number of pages | 5 |
Journal | Cancer Genetics and Cytogenetics |
Volume | 196 |
Issue number | 2 |
DOIs | |
State | Published - Jan 15 2010 |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research