Loss of pregnancy-associated plasma protein A extends lifespan in mice

Cheryl A Conover, Laurie K. Bale

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Genetic deletion in mice of pregnancy-associated plasma protein A (PAPP-A), a recently identified metalloproteinase in the insulin-like growth factor system, extends by 30-40% both mean and maximum lifespan with no reduction in food intake or secondary endocrine abnormalities. Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP-A as a critical regulator of lifespan and age-related diseases, and suggest PAPP-A as a possible target to promote longevity.

Original languageEnglish (US)
Pages (from-to)727-729
Number of pages3
JournalAging Cell
Volume6
Issue number5
DOIs
StatePublished - Oct 2007

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Pregnancy-Associated Plasma Protein-A
Metalloproteases
Somatomedins
Eating
Incidence
Neoplasms

Keywords

  • Gene knock-out
  • Insulin-like growth factor I
  • Longevity
  • Mouse model
  • Pregnancy-associated plasma protein A
  • Tumors

ASJC Scopus subject areas

  • Cell Biology

Cite this

Loss of pregnancy-associated plasma protein A extends lifespan in mice. / Conover, Cheryl A; Bale, Laurie K.

In: Aging Cell, Vol. 6, No. 5, 10.2007, p. 727-729.

Research output: Contribution to journalArticle

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