Loss of Peristaltic Reserve, Determined by Multiple Rapid Swallows, Is the Most Frequent Esophageal Motility Abnormality in Patients With Systemic Sclerosis

Dustin A. Carlson, Michael D. Crowell, Jessica N. Kimmel, Amit Patel, C. Prakash Gyawali, Monique Hinchcliff, W. Leroy Griffing, John E. Pandolfino, Marcelo F. Vela

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22 Scopus citations

Abstract

We assessed peristaltic reserve using multiple rapid swallows (MRS) during esophageal high-resolution manometry (HRM) of 111 patients with systemic sclerosis (89 women; ages, 42–64 y). We performed a retrospective analysis of HRM studies that included MRS in patients with systemic sclerosis, performed at 2 tertiary referral centers, and compared data with those from 18 healthy volunteers (controls). HRM findings were analyzed according to the Chicago Classification to provide an esophageal motility diagnosis. Response to MRS was evaluated for the presence of contraction and for augmentation, defined as the distal contractile integral after MRS greater than the median distal contractile integral of 10 supine swallows. Esophageal motility diagnoses included 41% with absent contractility, 31% with normal motility, 23% with ineffective esophageal motility, and 5% that met the criteria for other esophageal motility disorders. Contraction (37%) and peristaltic augmentation (18%) after MRS were observed less frequently in patients with systemic sclerosis than in controls (83% and 100%, respectively). Impaired peristaltic reserve, as assessed with MRS during HRM, is therefore the most common esophageal motility finding among patients with systemic sclerosis.

Original languageEnglish (US)
Pages (from-to)1502-1506
Number of pages5
JournalClinical Gastroenterology and Hepatology
Volume14
Issue number10
DOIs
StatePublished - Oct 1 2016

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Keywords

  • Esophageal Motility
  • High-Resolution Manometry
  • Systemic Sclerosis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Carlson, D. A., Crowell, M. D., Kimmel, J. N., Patel, A., Gyawali, C. P., Hinchcliff, M., Griffing, W. L., Pandolfino, J. E., & Vela, M. F. (2016). Loss of Peristaltic Reserve, Determined by Multiple Rapid Swallows, Is the Most Frequent Esophageal Motility Abnormality in Patients With Systemic Sclerosis. Clinical Gastroenterology and Hepatology, 14(10), 1502-1506. https://doi.org/10.1016/j.cgh.2016.03.039