Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging

Walter A Rocca, Liliana Gazzuola Rocca, Carin Y. Smith, Brandon R. Grossardt, Stephanie S. Faubion, Lynne T. Shuster, James L Kirkland, Nathan K LeBrasseur, Marissa J. Schafer, Michelle M Mielke, Kejal M Kantarci, Elizabeth A Stewart, Virginia M Miller

Research output: Contribution to journalArticle

10 Scopus citations


Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.

Original languageEnglish (US)
Pages (from-to)374-383
Number of pages10
JournalPhysiology (Bethesda, Md.)
Issue number6
StatePublished - Nov 1 2018


ASJC Scopus subject areas

  • Physiology

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