TY - JOUR
T1 - Loss of ovarian hormones and accelerated somatic and mental aging
AU - Rocca, Walter A.
AU - Rocca, Liliana Gazzuola
AU - Smith, Carin Y.
AU - Grossardt, Brandon R.
AU - Faubion, Stephanie S.
AU - Shuster, Lynne T.
AU - Kirkland, James L.
AU - Lebrasseur, Nathan K.
AU - Schafer, Marissa J.
AU - Mielke, Michelle M.
AU - Kantarci, Kejal
AU - Stewart, Elizabeth A.
AU - Miller, Virginia M.
N1 - Funding Information:
The authors were partly supported by National Institute on Aging Grants R01 AG-034676, R01 AG-052425, P50 AG-044170, U01 AG-006786, and P01 AG-004875 (to W.A.R.); P50 AG-044170 (to V.M.M.); R37 AG-013925 (to J.L.K.); and R56 AG-052958 and R01 AG-052964 (to N.K.L.). J.L.K. was also partly supported by the Ted Nash Long Life and Noaber Foundations. S.S.F. reports consulting fees from Mithra Pharmaceuticals and Procter & Gamble. E.A.S. reports grants from the National Institutes of Health and consulting fees from Ab-bVie, Bayer, GlaxoSmithKline, Gynesonics, Astellas Pharmaceuticals, Welltwigs, Viteava Pharmaceuticals, and Allergan, outside the submitted work. In addition, E.A.S. has a patent: Methods and Compounds for Treatment of Abnormal Uterine Bleeding (US 6440445 issued to None). K.K. serves on the data safety monitoring board for Takeda Global Research & Development Center, Inc. She receives research funding from the NIH, Alzheimer’s Drug and Discovery Foundation, and Avid Radiopharmaceuticals, Eli Lilly. M.M.M. served as a consultant to Eli Lilly and Lysosomal Therapeutics, Inc. She receives research support from the National Institute on Aging (R01 AG-049704, P50 AG-044170, U01 AG-006786, RF1 AG-055151), Department of Defense (W81XWH-15-1), and unrestricted research grants from Biogen and Lundbeck.
Publisher Copyright:
© 2018, American Physiological Society. All rights reserved.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.
AB - Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.
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U2 - 10.1152/physiol.00024.2018
DO - 10.1152/physiol.00024.2018
M3 - Review article
C2 - 30303778
AN - SCOPUS:85054741341
VL - 33
SP - 374
EP - 383
JO - Physiology
JF - Physiology
SN - 1548-9213
IS - 6
ER -