TY - JOUR
T1 - Loss of ovarian hormones and accelerated somatic and mental aging
AU - Rocca, Walter A.
AU - Rocca, Liliana Gazzuola
AU - Smith, Carin Y.
AU - Grossardt, Brandon R.
AU - Faubion, Stephanie S.
AU - Shuster, Lynne T.
AU - Kirkland, James L.
AU - Lebrasseur, Nathan K.
AU - Schafer, Marissa J.
AU - Mielke, Michelle M.
AU - Kantarci, Kejal
AU - Stewart, Elizabeth A.
AU - Miller, Virginia M.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.
AB - Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.
UR - http://www.scopus.com/inward/record.url?scp=85054741341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054741341&partnerID=8YFLogxK
U2 - 10.1152/physiol.00024.2018
DO - 10.1152/physiol.00024.2018
M3 - Review article
C2 - 30303778
AN - SCOPUS:85054741341
VL - 33
SP - 374
EP - 383
JO - Physiology
JF - Physiology
SN - 1548-9213
IS - 6
ER -