Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging

Walter A Rocca; Liliana Gazzuola Rocca; Carin Y. Smith; Brandon R. Grossardt; Stephanie S. Faubion; Lynne T. Shuster; James L Kirkland; Nathan K LeBrasseur; Marissa J. Schafer; Michelle M Mielke; Kejal M Kantarci; Elizabeth A Stewart; Virginia M Miller

doi:10.1152/physiol.00024.2018

Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging

Walter A Rocca, Liliana Gazzuola Rocca, Carin Y. Smith, Brandon R. Grossardt, Stephanie S. Faubion, Lynne T. Shuster, James L Kirkland, Nathan K LeBrasseur, Marissa J. Schafer, Michelle M Mielke, Kejal M Kantarci, Elizabeth A Stewart, Virginia M Miller

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.

Original language	English (US)
Pages (from-to)	374-383
Number of pages	10
Journal	Physiology (Bethesda, Md.)
Volume	33
Issue number	6
DOIs	https://doi.org/10.1152/physiol.00024.2018
State	Published - Nov 1 2018

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ASJC Scopus subject areas

Physiology

Cite this

Rocca, W. A., Gazzuola Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., LeBrasseur, N. K., Schafer, M. J., Mielke, M. M., Kantarci, K. M., Stewart, E. A., & Miller, V. M. (2018). Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging. Physiology (Bethesda, Md.), 33(6), 374-383. https://doi.org/10.1152/physiol.00024.2018

Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging. / Rocca, Walter A; Gazzuola Rocca, Liliana; Smith, Carin Y.; Grossardt, Brandon R.; Faubion, Stephanie S.; Shuster, Lynne T.; Kirkland, James L ; LeBrasseur, Nathan K; Schafer, Marissa J.; Mielke, Michelle M ; Kantarci, Kejal M ; Stewart, Elizabeth A ; Miller, Virginia M.

In: Physiology (Bethesda, Md.), Vol. 33, No. 6, 01.11.2018, p. 374-383.

Research output: Contribution to journal › Article

Rocca, Walter A ; Gazzuola Rocca, Liliana ; Smith, Carin Y. ; Grossardt, Brandon R. ; Faubion, Stephanie S. ; Shuster, Lynne T. ; Kirkland, James L ; LeBrasseur, Nathan K ; Schafer, Marissa J. ; Mielke, Michelle M ; Kantarci, Kejal M ; Stewart, Elizabeth A ; Miller, Virginia M. / Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging. In: Physiology (Bethesda, Md.). 2018 ; Vol. 33, No. 6. pp. 374-383.

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10.1152/physiol.00024.2018