Aims: Phosphate balance in uremic patients represents a dramatic problem, which contributes to their increased morbidity and mortality. We have shown that salivary phosphate secretion is higher both in dialysis (HD) and in chronic renal failure patients (CRF) compared with healthy subjects, closely related with serum phosphorous and may contribute to their increased phosphate balance. The presence of a circadian rhythm of salivary phosphate secretion with early evening acrophases in healthy subjects and our demonstration of increased salivary phosphate secretion both in HD and CRF have prompted us to check for possible abnormalities of the circadian rhythm of salivary phosphate secretion in uremic patients. Methods: Salivary phosphate secretion at 8.00, 12.00 a.m. and at 05.00 pm and 10.00 p.m. was evaluated in 56 HD patients without residual diuresis. 19 healthy subjects age and sex matched were used as control group. Results: Higher salivary phosphate secretion was confirmed in HD patients compared to healthy subjects: 43.77 mg/dl ± 20.61 at the day of dialysis and 44.75 ± 23.04 at the dialysis free day vs 19.63 ± 2.94, p < 0.0001. Contrary to healthy subjects, HD patients' salivary phosphate secretion was higher throughout the day without any circadian rhythm. Conclusion: The results of this study add new considerations for a possible therapeutic approach to hyperphosphatemia in uremic patients based on the reduction of salivary phosphate secretion.
|Translated title of the contribution||Loss of acrophase in the circadian rhythm of salivary phosphate secretion in hemodialysis patients. Implications for hyperphosphatemia|
|Number of pages||3|
|Journal||Aktuality v Nefrologii|
|State||Published - Mar 24 2009|
- Salivary phosphate
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